Evidence map›Paper›PMID 34770896›Full record

ArticleMolecules (Basel, Switzerland)2021

Evaluation of the Inhibitory Effects of Pyridylpyrazole Derivatives on LPS-Induced PGE

Mahmoud M Gamal El-Din, Mohammed I El-Gamal, Young-Do Kwon, Su-Yeon Kim, Hee-Soo Han, Sang-Eun Park, Chang-Hyun Oh, Kyung-Tae Lee, Hee-Kwon Kim

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Molecules (Basel, Switzerland), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.2field-weighted citation impact, top 43% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 2 citations in OpenAlex.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 5 institutions in 3 countries.

Mahmoud M Gamal El-DinNational Research Centre, Pharmaceutical and Drug Industries Research Division, Dokki-Giza 12622, Egypt.
Mohammed I El-GamalDepartment of Medicinal Chemistry, College of Pharmacy, University of Sharjah, Sharjah 27272, United Arab Emirates.ORCID 0000-0002-4269-5264
Young-Do KwonMolecular Imaging & Therapeutic Medicine Research Center, Department of Nuclear Medicine, Jeonbuk National University Medical School and Hospital, 20 Geonji-ro, Deokjin-gu, Jeonju 54907, Korea.
Su-Yeon KimDepartment of Pharmaceutical Biochemistry, Kyung Hee University, Seoul 02447, Korea.
Hee-Soo HanDepartment of Pharmaceutical Biochemistry, Kyung Hee University, Seoul 02447, Korea.
Sang-Eun ParkDepartment of Pharmaceutical Biochemistry, Kyung Hee University, Seoul 02447, Korea.
Chang-Hyun OhCenter for Biomaterials, Korea Institute of Science and Technology, P.O. Box 131, Cheongryang, Seoul 130-650, Korea.
Kyung-Tae LeeDepartment of Pharmaceutical Biochemistry, Kyung Hee University, Seoul 02447, Korea.ORCID 0000-0002-3141-3727
Hee-Kwon KimMolecular Imaging & Therapeutic Medicine Research Center, Department of Nuclear Medicine, Jeonbuk National University Medical School and Hospital, 20 Geonji-ro, Deokjin-gu, Jeonju 54907, Korea.ORCID 0000-0001-7612-7049
Kyung Hee University · KRJeonbuk National University Hospital · KRKorea Institute of Science and Technology · KRMansoura University · EGNational Research Centre · EG

Funding

National Research Foundation of Korea NRF-2021R1A2C1011204
6 · The paper itself

Abstract

A series of thirteen triarylpyrazole analogs were investigated as inhibitors of lipopolysaccharide (LPS)-induced prostaglandin E

Indexed as

AnimalsAnti-Inflammatory AgentsDinoprostoneDose-Response Relationship, DrugLipopolysaccharidesMacrophagesMiceMolecular StructureNitric OxidePyrazolesRAW 264.7 CellsStructure-Activity RelationshipAnti-Inflammatory AgentsDinoprostoneLipopolysaccharidesNitric OxidepyrazolePyrazolesamideanti-inflammatoryCOX-2iNOSNOPGE2pyrazole

Identifiers

PMID34770896
PMCPMC8587869
OpenAlexW3210202656

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.