Evidence map›Paper›PMID 34770863›Full record

ReviewMolecules (Basel, Switzerland)2021

A Review of Human Coronaviruses' Receptors: The Host-Cell Targets for the Crown Bearing Viruses.

Aaya Nassar, Ibrahim M Ibrahim, Fatma G Amin, Merna Magdy, Ahmed M Elgharib, Eman B Azzam, Filopateer Nasser, Kirllos Yousry, Israa M Shamkh, Samah M Mahdy and 1 more

Open access · goldAbstract readReview
In one paragraph

Review in Molecules (Basel, Switzerland), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 37 papers.

0numbers the graph read from it
0cells of the map it votes in
37citing papers in PubMed
3.8field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

37 citing papers in PubMed, 58 citations in OpenAlex.

  1. Article
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  5. Identification ofMolecules (Basel, Switzerland) · 2025
    Article
  6. Article
  7. Article
  8. International journal of molecular sciences · 2024
    Article
  9. Review
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  11. SARS-CoV-2 nsp15 endoribonuclease antagonizes dsRNA-induced antiviral signaling.Proceedings of the National Academy of Sciences of the United States of America · 2024
    Article
  12. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 3 institutions in 1 country.

Aaya NassarBiophysics Department, Faculty of Science, Cairo University, Giza 12511, Egypt.ORCID 0000-0002-5542-9387
Ibrahim M IbrahimBiophysics Department, Faculty of Science, Cairo University, Giza 12511, Egypt.
Fatma G AminBiophysics Department, Faculty of Science, Cairo University, Giza 12511, Egypt.
Merna MagdyBiophysics Department, Faculty of Science, Cairo University, Giza 12511, Egypt.
Ahmed M ElgharibBiophysics Department, Faculty of Science, Cairo University, Giza 12511, Egypt.
Eman B AzzamPhysics Department, Medical Biophysics Division, Faculty of Science, Helwan University, Cairo 11511, Egypt.
Filopateer NasserBiochemistry Department, Faculty of Science, Cairo University, Giza 12511, Egypt.ORCID 0000-0002-1086-4705
Kirllos YousryFaculty of Medicine, Cairo University, Cairo 11511, Egypt.
Israa M ShamkhIndependent Researcher, Giza 12511, Egypt.
Samah M MahdyNational Museum of Egyptian Civilization, Ain Elsira-Elfustat, Cairo 11511, Egypt.
Abdo A ElfikyBiophysics Department, Faculty of Science, Cairo University, Giza 12511, Egypt.
Cairo University · EGEgyptian Museum · EGHelwan University · EG

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

A novel human coronavirus prompted considerable worry at the end of the year 2019. Now, it represents a significant global health and economic burden. The newly emerged coronavirus disease caused by the severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) is the primary reason for the COVID-19 global pandemic. According to recent global figures, COVID-19 has caused approximately 243.3 million illnesses and 4.9 million deaths. Several human cell receptors are involved in the virus identification of the host cells and entering them. Hence, understanding how the virus binds to host-cell receptors is crucial for developing antiviral treatments and vaccines. The current work aimed to determine the multiple host-cell receptors that bind with SARS-CoV-2 and other human coronaviruses for the purpose of cell entry. Extensive research is needed using neutralizing antibodies, natural chemicals, and therapeutic peptides to target those host-cell receptors in extremely susceptible individuals. More research is needed to map SARS-CoV-2 cell entry pathways in order to identify potential viral inhibitors.

Indexed as

Antibodies, NeutralizingAntiviral AgentsCoronavirusCOVID-19Host Microbial InteractionsHumansReceptors, CoronavirusReceptors, VirusSARS-CoV-2Spike Glycoprotein, CoronavirusVirus InternalizationAntibodies, NeutralizingAntiviral AgentsReceptors, CoronavirusReceptors, VirusSpike Glycoprotein, Coronaviruscell receptorCOVID-19human coronavirusSARS-CoV-2spikeviral entry

Identifiers

PMID34770863
PMCPMC8587140
OpenAlexW3211315396

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.