Evidence map›Paper›PMID 34770861›Full record

ReviewMolecules (Basel, Switzerland)2021

Use of Polyhedral Oligomeric Silsesquioxane (POSS) in Drug Delivery, Photodynamic Therapy and Bioimaging.

Paula Loman-Cortes, Tamanna Binte Huq, Juan L Vivero-Escoto

Abstract readReview
In one paragraph

Review in Molecules (Basel, Switzerland), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.

0numbers the graph read from it
0cells of the map it votes in
19citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

19 citing papers in PubMed.

  1. Article
  2. Preparation of NHACS omega · 2026
    Article
  3. Liquid Trisilanol i-Octyl POSS Achieves Rapid Hemostasis and Pneumostasis in Experimental Lung Injury.Pathophysiology : the official journal of the International Society for Pathophysiology · 2025
    Article
  4. Article
  5. Article
  6. Review
  7. Article
  8. Article
  9. Article
  10. Article
  11. Visualizable and Lubricating Hydrogel Microspheres Via NanoPOSS for Cartilage Regeneration.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2023
    Article
  12. Review
  13. Review
  14. Article
  15. Article
  16. Review
  17. Review
  18. Review
  19. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Paula Loman-CortesDepartment of Chemistry, The University of North Carolina at Charlotte, Charlotte, NC 28223, USA.
Tamanna Binte HuqDepartment of Chemistry, The University of North Carolina at Charlotte, Charlotte, NC 28223, USA.
Juan L Vivero-EscotoDepartment of Chemistry, The University of North Carolina at Charlotte, Charlotte, NC 28223, USA.ORCID 0000-0001-7400-2963

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Polyhedral oligomeric silsesquioxanes (POSS) have attracted considerable attention in the design of novel organic-inorganic hybrid materials with high performance capabilities. Features such as their well-defined nanoscale structure, chemical tunability, and biocompatibility make POSS an ideal building block to fabricate hybrid materials for biomedical applications. This review highlights recent advances in the application of POSS-based hybrid materials, with particular emphasis on drug delivery, photodynamic therapy and bioimaging. The design and synthesis of POSS-based materials is described, along with the current methods for controlling their chemical functionalization for biomedical applications. We summarize the advantages of using POSS for several drug delivery applications. We also describe the current progress on using POSS-based materials to improve photodynamic therapies. The use of POSS for delivery of contrast agents or as a passivating agent for nanoprobes is also summarized. We envision that POSS-based hybrid materials have great potential for a variety of biomedical applications including drug delivery, photodynamic therapy and bioimaging.

Indexed as

Drug Delivery SystemsOptical ImagingPhotochemotherapyContrast MediaHumansOrganosilicon CompoundsContrast MediaOrganosilicon Compoundspolysilsesquioxanebiomedical applicationsdrug delivery systems (DDS)imagingphotodynamic therapy (PDT)polyhedral oligomeric silsesquioxane (POSS)

Identifiers

PMID34770861
PMCPMC8588151

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.