Evidence map›Paper›PMID 34770796›Full record

ReviewMolecules (Basel, Switzerland)2021

Green Synthesis of Gold Nanoparticles Using Plant Extracts as Beneficial Prospect for Cancer Theranostics.

Kaushik Kumar Bharadwaj, Bijuli Rabha, Siddhartha Pati, Tanmay Sarkar, Bhabesh Kumar Choudhury, Arpita Barman, Dorothy Bhattacharjya, Ankit Srivastava, Debabrat Baishya, Hisham Atan Edinur and 2 more

Open access · goldAbstract readReview
In one paragraph

Review in Molecules (Basel, Switzerland), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 81 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
81citing papers in PubMed, 1 pooled it
11.5field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

81 citing papers in PubMed, 1 synthesis or guideline pooled it, 245 citations in OpenAlex.

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21 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 5 institutions in 2 countries.

Kaushik Kumar BharadwajDepartment of Bioengineering & Technology, GUIST, Gauhati University, Guwahati 781014, Assam, India.ORCID 0000-0002-4027-487X
Bijuli RabhaDepartment of Bioengineering & Technology, GUIST, Gauhati University, Guwahati 781014, Assam, India.
Siddhartha PatiSIAN Institute, Association for Biodiversity Conservation and Research (ABC), Balasore 756001, Odisha, India.ORCID 0000-0002-8276-0008
Tanmay SarkarMalda Polytechnic, West Bengal State Council of Technical Education, Government of West Benga, Malda 732102, West Bengal, India.ORCID 0000-0003-3869-1604
Bhabesh Kumar ChoudhuryDepartment of Chemistry, Gauhati University, Guwahati 781014, Assam, India.ORCID 0000-0001-8640-8856
Arpita BarmanDepartment of Bioengineering & Technology, GUIST, Gauhati University, Guwahati 781014, Assam, India.
Dorothy BhattacharjyaDepartment of Bioengineering & Technology, GUIST, Gauhati University, Guwahati 781014, Assam, India.
Ankit SrivastavaDepartment of Biotechnology, Motilal Nehru National Institute of Technology, Allahabad (Prayagraj) 211004, Uttar Pradesh, India.ORCID 0000-0003-2076-879X
Debabrat BaishyaDepartment of Bioengineering & Technology, GUIST, Gauhati University, Guwahati 781014, Assam, India.
Hisham Atan EdinurSchool of Health Sciences, Health Campus, Universiti Sains Malaysia, Kubang Kerian 16150, Kelantan, Malaysia.ORCID 0000-0002-3379-6063
Zulhisyam Abdul KariFaculty of Agro Based Industry, Universiti Malaysia Kelantan, Jeli 17600, Kelantan, Malaysia.ORCID 0000-0002-3160-7839
Noor Haslina Mohd NoorHaematology Department, School of Medical Sciences, Universiti Sains Malaysia Health Campus, Kubang Kerian 16150, Kelantan, Malaysia.
Gauhati University · INUniversiti Sains Malaysia · MYJadavpur University · INMotilal Nehru National Institute of Technology · INUniversiti Malaysia Kelantan · MY

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Gold nanoparticles (AuNPs) have been widely explored and are well-known for their medical applications. Chemical and physical synthesis methods are a way to make AuNPs. In any case, the hunt for other more ecologically friendly and cost-effective large-scale technologies, such as environmentally friendly biological processes known as green synthesis, has been gaining interest by worldwide researchers. The international focus on green nanotechnology research has resulted in various nanomaterials being used in environmentally and physiologically acceptable applications. Several advantages over conventional physical and chemical synthesis (simple, one-step approach to synthesize, cost-effectiveness, energy efficiency, and biocompatibility) have drawn scientists' attention to exploring the green synthesis of AuNPs by exploiting plants' secondary metabolites. Biogenic approaches, mainly the plant-based synthesis of metal nanoparticles, have been chosen as the ideal strategy due to their environmental and in vivo safety, as well as their ease of synthesis. In this review, we reviewed the use of green synthesized AuNPs in the treatment of cancer by utilizing phytochemicals found in plant extracts. This article reviews plant-based methods for producing AuNPs, characterization methods of synthesized AuNPs, and discusses their physiochemical properties. This study also discusses recent breakthroughs and achievements in using green synthesized AuNPs in cancer treatment and different mechanisms of action, such as reactive oxygen species (ROS), mediated mitochondrial dysfunction and caspase activation, leading to apoptosis, etc., for their anticancer and cytotoxic effects. Understanding the mechanisms underlying AuNPs therapeutic efficacy will aid in developing personalized medicines and treatments for cancer as a potential cancer therapeutic strategy.

Indexed as

GoldGreen Chemistry TechnologyMetal NanoparticlesAnimalsAntineoplastic AgentsCell Line, TumorCell SurvivalChemical PhenomenaDiagnostic ImagingHumansNanoparticle Drug Delivery SystemPhytochemicalsPlant ExtractsTheranostic NanomedicineAntineoplastic AgentsGoldNanoparticle Drug Delivery SystemPhytochemicalsPlant ExtractsanticancerAuNPsgold nanoparticlesgreen synthesisplantstherapy

Identifiers

PMID34770796
PMCPMC8586976
OpenAlexW3210117516

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.