Evidence map›Paper›PMID 34770788›Full record

ArticleMolecules (Basel, Switzerland)2021

Fractionation of Lycopodiaceae Alkaloids and Evaluation of Their Anticholinesterase and Cytotoxic Activities.

Aleksandra Dymek, Jarosław Widelski, Krzysztof Kamil Wojtanowski, Vladyslav Vivcharenko, Agata Przekora, Tomasz Mroczek

Open access · goldAbstract read
In one paragraph

Article in Molecules (Basel, Switzerland), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
1.3field-weighted citation impact, top 20% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 11 citations in OpenAlex.

  1. Article
  2. Article
  3. Journal of clinical medicine · 2022
    Article
  4. Antifungal Sesquiterpenoids fromMolecules (Basel, Switzerland) · 2022
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Aleksandra DymekIndependent Laboratory of Chemistry of Natural Products, Medical University of Lublin, 1 Chodzki St., 20-093 Lublin, Poland.
Jarosław WidelskiIndependent Laboratory of Chemistry of Natural Products, Medical University of Lublin, 1 Chodzki St., 20-093 Lublin, Poland.ORCID 0000-0003-3154-9138
Krzysztof Kamil WojtanowskiIndependent Laboratory of Chemistry of Natural Products, Medical University of Lublin, 1 Chodzki St., 20-093 Lublin, Poland.
Vladyslav VivcharenkoIndependent Unit of Tissue Engineering and Regenerative Medicine, Medical University of Lublin, 1 Chodzki St., 20-093 Lublin, Poland.ORCID 0000-0002-1526-686X
Agata PrzekoraIndependent Unit of Tissue Engineering and Regenerative Medicine, Medical University of Lublin, 1 Chodzki St., 20-093 Lublin, Poland.ORCID 0000-0002-6076-1309
Tomasz MroczekIndependent Laboratory of Chemistry of Natural Products, Medical University of Lublin, 1 Chodzki St., 20-093 Lublin, Poland.ORCID 0000-0002-5267-7182
Medical University of Lublin · PL

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

In view of the abundant evidence that Lycopodiaceae alkaloids, including the well-known huperzine A (HupA), are among the potent acetylcholinesterase (AChE) inhibitors, an attempt was made to search for new compounds responsible for this property. For this purpose, three plant species belonging to the Lycopodiaceae family, commonly found in the Euro-Asia region, were subjected to the isolation of bioactive compounds, their identification and subsequent evaluation of their anticholinesterase and cytotoxic activities. Methanolic extracts of two

Indexed as

AlkaloidsCell SurvivalChemical FractionationCholinesterase InhibitorsChromatography, High Pressure LiquidFibroblastsLycopodiaceaeMolecular StructurePlant ExtractsSpectrometry, Mass, Matrix-Assisted Laser Desorption-IonizationAlkaloidsCholinesterase InhibitorsPlant ExtractsAChE inhibitorsalkaloidsHPLC/ESI-QTOF-MSHuperzia selago L.LycopodiaceaeLycopodium annotinum L.Lycopodium clavatum L.TLC bioautographyVLC

Identifiers

PMID34770788
PMCPMC8588253
OpenAlexW3208770920

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.