Evidence map›Paper›PMID 34770786›Full record

ArticleMolecules (Basel, Switzerland)2021

Betulinic Acid Modulates the Expression of HSPA and Activates Apoptosis in Two Cell Lines of Human Colorectal Cancer.

Laphatrada Yurasakpong, Chanin Nantasenamat, Saksit Nobsathian, Kulathida Chaithirayanon, Somjai Apisawetakan

Open access · goldAbstract read
In one paragraph

Article in Molecules (Basel, Switzerland), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
0.2field-weighted citation impact, top 46% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 7 citations in OpenAlex.

  1. Betulinic acid isolated fromHistology and histopathology · 2026
    Article
  2. The therapeutic potential ofAvicenna journal of phytomedicine · 2026
    Article
  3. Article
  4. Histone Modification of Colorectal Cancer by Natural Products.Pharmaceuticals (Basel, Switzerland) · 2023
    Review
  5. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 1 country.

Laphatrada YurasakpongDepartment of Anatomy, Faculty of Science, Mahidol University, Rama VI Road, Ratchathewi, Bangkok 10400, Thailand.
Chanin NantasenamatCenter of Data Mining and Biomedical Informatics, Faculty of Medical Technology, Mahidol University, Bangkok 10700, Thailand.ORCID 0000-0003-1040-663X
Saksit NobsathianNakornsawan Campus, Mahidol University, Nakonsawan 60130, Thailand.
Kulathida ChaithirayanonDepartment of Anatomy, Faculty of Science, Mahidol University, Rama VI Road, Ratchathewi, Bangkok 10400, Thailand.ORCID 0000-0001-7351-7877
Somjai ApisawetakanDepartment of Anatomy, Faculty of Medicine, Srinakharinwirot University, Wattana, Bangkok 10110, Thailand.
Mahidol University · THSrinakharinwirot University · TH

Funding

Srinakharinwirot University (Government Budget Grant) 003/2562
6 · The paper itself

Abstract

Betulinic acid (BA) is a pentacyclic triterpene usually isolated from botanical sources. Numerous studies have reported the inhibitory effect of BA against human colorectal cancer cells (CRC). However, its effect on the expression of the molecular chaperone HSPA is unclear. The aim of this research is to investigate the anti-cancer activities of BA purified from

Indexed as

Antineoplastic Agents, PhytogenicApoptosisBetulinic AcidCell Line, TumorCell ProliferationCell SurvivalColorectal NeoplasmsDose-Response Relationship, DrugFlow CytometryGene Expression Regulation, NeoplasticHSP70 Heat-Shock ProteinsHumansMolecular ConformationMolecular Docking SimulationMolecular Dynamics SimulationPentacyclic TriterpenesAntineoplastic Agents, PhytogenicBetulinic AcidHSP70 Heat-Shock ProteinsPentacyclic Triterpenesapoptosisbetulinic acidcolorectal cancerHSPA

Identifiers

PMID34770786
PMCPMC8588033
OpenAlexW3206063480

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.