Evidence map›Paper›PMID 34770770›Full record

ArticleMolecules (Basel, Switzerland)2021

Alterations in β-Cell Sphingolipid Profile Associated with ER Stress and iPLA

Tomader Ali, Xiaoyong Lei, Suzanne E Barbour, Akio Koizumi, Charles E Chalfant, Sasanka Ramanadham

Open access · goldAbstract read
In one paragraph

Article in Molecules (Basel, Switzerland), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.2field-weighted citation impact, top 46% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 7 citations in OpenAlex.

  1. Article
  2. The PNPLA family of enzymes: characterisation and biological role.Arhiv za higijenu rada i toksikologiju · 2023
    Article
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 5 institutions in 3 countries.

Tomader AliResearch Department, Imperial College London Diabetes Center, Abu Dhabi 51133, United Arab Emirates.ORCID 0000-0002-9327-2675
Xiaoyong LeiDepartment of Cell, Developmental, and Integrative Biology and Comprehensive Diabetes Center, University of Alabama at Birmingham, Birmingham, AL 35294, USA.
Suzanne E BarbourDepartment of Biochemistry and Biophysics, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA.
Akio KoizumiDepartment of Health and Environmental Sciences, Kyoto Graduate School of Medicine, Kyoto 606-8501, Japan.
Charles E ChalfantDepartment of Cell Biology, Microbiology and Molecular Biology, University of South Florida, Tampa, FL 33620, USA.
Sasanka RamanadhamDepartment of Cell, Developmental, and Integrative Biology and Comprehensive Diabetes Center, University of Alabama at Birmingham, Birmingham, AL 35294, USA.ORCID 0000-0002-1664-0657
University of Alabama at Birmingham · USImperial College London Diabetes Centre · AEKyoto College of Medical Science · JPUniversity of North Carolina at Chapel Hill · USUniversity of South Florida · US

Funding

University of Alabama at Birmingham's Diabetes Research CenterP30DK079626 · NIDDK · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI Stuart J Frank · 2013 to 2026
$19.5M
iPLA2beta-mediated alternative splicing and -cell death in type 1 diabetesR01DK126444 · NIDDK · UNIVERSITY OF VIRGINIA · PI CHALFANT, CHARLES E., EIZIRIK, DECIO LAKS · 2021 to 2024
$2.0M
BLRD Research Career Scientist Award ApplicationIK6BX004603 · VA · VA VETERANS ADMINISTRATION HOSPITAL · PI CHALFANT, CHARLES E. · 2019 to 2025
–
BLRD VA IK6 BX004603NIDDK NIH HHS P30 DK079626NIDDK NIH HHS R01 DK126444
6 · The paper itself

Abstract

Type 1 diabetes (T1D) development, in part, is due to ER stress-induced β-cell apoptosis. Activation of the Ca

Indexed as

ApoptosisEndoplasmic Reticulum StressAcyltransferasesCell LineChromatography, LiquidDiabetes Mellitus, Type 1Gene ExpressionHumansInsulin-Secreting CellsLipaseLipidomicsMembrane ProteinsModels, BiologicalPhospholipases A2, Calcium-IndependentSphingolipidsTandem Mass SpectrometryAcyltransferasesLipaseMembrane ProteinsPhospholipases A2, Calcium-IndependentPNPLA3 protein, humanSphingolipidsapoptosisdiabetesphospholipase A2sphingolipids

Identifiers

PMID34770770
PMCPMC8587436
OpenAlexW3205384294

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.