Evidence map›Paper›PMID 34770565›Full record

SynthesisSensors (Basel, Switzerland)2021

Transfer Learning for Alzheimer's Disease through Neuroimaging Biomarkers: A Systematic Review.

Deevyankar Agarwal, Gonçalo Marques, Isabel de la Torre-Díez, Manuel A Franco Martin, Begoña García Zapiraín, Francisco Martín Rodríguez

Abstract readSystematic Review
In one paragraph

Synthesis in Sensors (Basel, Switzerland), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.

0numbers the graph read from it
0cells of the map it votes in
22citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

22 citing papers in PubMed.

  1. Trial
  2. Article
  3. Article
  4. Article
  5. Personalized prevention of neurodegenerative diseases: scoping review and evidence gap map.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2025
    Article
  6. Article
  7. Article
  8. Article
  9. Review
  10. Review
  11. Article
  12. Article
  13. Article
  14. Article
  15. A robust class decomposition-based approach for detecting Alzheimer's progression.Experimental biology and medicine (Maywood, N.J.) · 2023
    Article
  16. Review
  17. Article
  18. Review
  19. Review
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Deevyankar AgarwalDepartment of Signal Theory and Communications and Telematics Engineering, University of Valladolid, Paseo de Belén 15, 47011 Valladolid, Spain.
Gonçalo MarquesDepartment of Signal Theory and Communications and Telematics Engineering, University of Valladolid, Paseo de Belén 15, 47011 Valladolid, Spain.ORCID 0000-0001-5834-6571
Isabel de la Torre-DíezDepartment of Signal Theory and Communications and Telematics Engineering, University of Valladolid, Paseo de Belén 15, 47011 Valladolid, Spain.ORCID 0000-0003-3134-7720
Manuel A Franco MartinPsychiatric Department, University Rio Hortega Hospital-Valladolid, 47011 Valladolid, Spain.ORCID 0000-0002-3639-2523
Begoña García ZapiraíneVIDA Laboratory, University of Deusto, Avenida de las Universidades 24, 48007 Bilbao, Spain.ORCID 0000-0002-9356-1186
Francisco Martín RodríguezAdvanced Clinical Simulation Center, School of Medicine, University of Valladolid, 47011 Valladolid, Spain.ORCID 0000-0002-1773-2860

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Alzheimer's disease (AD) is a remarkable challenge for healthcare in the 21st century. Since 2017, deep learning models with transfer learning approaches have been gaining recognition in AD detection, and progression prediction by using neuroimaging biomarkers. This paper presents a systematic review of the current state of early AD detection by using deep learning models with transfer learning and neuroimaging biomarkers. Five databases were used and the results before screening report 215 studies published between 2010 and 2020. After screening, 13 studies met the inclusion criteria. We noted that the maximum accuracy achieved to date for AD classification is 98.20% by using the combination of 3D convolutional networks and local transfer learning, and that for the prognostic prediction of AD is 87.78% by using pre-trained 3D convolutional network-based architectures. The results show that transfer learning helps researchers in developing a more accurate system for the early diagnosis of AD. However, there is a need to consider some points in future research, such as improving the accuracy of the prognostic prediction of AD, exploring additional biomarkers such as tau-PET and amyloid-PET to understand highly discriminative feature representation to separate similar brain patterns, managing the size of the datasets due to the limited availability.

Indexed as

Alzheimer DiseaseBiomarkersBrainHumansMachine LearningMagnetic Resonance ImagingNeuroimagingBiomarkersAlzheimer’s diseasemagnetic resonance imagingneuroimaging biomarkerspositron emission tomographytransfer learning

Identifiers

PMID34770565
PMCPMC8587338

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.