Evidence map›Paper›PMID 34770174›Full record

ArticleInternational journal of environmental research and public health2021

Effect of Water-Pipe Smoking on the Normal Development of Zebrafish.

Zain Zaki Zakaria, Shaima Ahmad Aladwi, Fatiha Benslimane, Enas S Al-Absi, Mashael Al-Shafai, Huseyin C Yalcin, Ashraf Khalil, Ala-Eddin Al Moustafa, Maha Al-Asmakh

Open access · goldAbstract read

PubMed Full text at PMC Publisher

In one paragraph

Article in International journal of environmental research and public health, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it

0cells of the map it votes in

1citing papers in PubMed

0.1field-weighted citation impact, top 57% of its field

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 2 citations in OpenAlex.

Impact of prolonged exposure to occasional and regular waterpipe smoke on cardiac injury, oxidative stress and mitochondrial dysfunction in male mice.Frontiers in physiology · 2024
Article

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 1 institution in 1 country.

Zain Zaki ZakariaDepartment of Biomedical Sciences, College of Health Sciences, QU Health, Qatar University, Doha P.O. Box 2713, Qatar.ORCID 0000-0002-9656-8367

Shaima Ahmad AladwiDepartment of Biomedical Sciences, College of Health Sciences, QU Health, Qatar University, Doha P.O. Box 2713, Qatar.

Fatiha BenslimaneBiomedical Research Center, Qatar University, Doha P.O. Box 2713, Qatar.ORCID 0000-0003-3792-252X

Enas S Al-AbsiDepartment of Biomedical Sciences, College of Health Sciences, QU Health, Qatar University, Doha P.O. Box 2713, Qatar.ORCID 0000-0003-2959-1732

Mashael Al-ShafaiDepartment of Biomedical Sciences, College of Health Sciences, QU Health, Qatar University, Doha P.O. Box 2713, Qatar.

Huseyin C YalcinBiomedical Research Center, Qatar University, Doha P.O. Box 2713, Qatar.ORCID 0000-0003-3825-9934

Ashraf KhalilBiomedical and Pharmaceutical Research Unit, QU Health, Qatar University, Doha P.O. Box 2713, Qatar.

Ala-Eddin Al MoustafaBiomedical Research Center, Qatar University, Doha P.O. Box 2713, Qatar.ORCID 0000-0003-4452-3439

Maha Al-AsmakhDepartment of Biomedical Sciences, College of Health Sciences, QU Health, Qatar University, Doha P.O. Box 2713, Qatar.

Qatar University · QA

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundAmong all types of tobacco consumption, Water-Pipe Smoking (WPS) is the most widely used in the Middle East and second-most in several other countries. The effect of WPS on normal development is not yet fully understood, thus the aim of this study is to explore the acute toxicity effects of WPS extract on zebrafish larvae.

methodsIn this study, we compared the effects of WPS smoke condensates at concentrations varying from 50 to 200 µg/mL on developmental, cardiac, and behavioural (neurotoxicity) functions. Gene expression patterns of cardiac biomarkers were also evaluated by RT-qPCR.

resultsExposing zebrafish embryos to 50, 100, 150 and 200 µg/mL WPS for three days did not affect the normal morphology of Zebrafish embryos, as the tail flicking, behavioural and locomotion assays did not show any change. However, WPS deregulated cardiac markers including atrial natriuretic peptide (ANP/NPPA) and brain natriuretic peptide (BNP/NPPB). Furthermore, it induced apoptosis in a dose-dependent manner.

conclusionOur data demonstrate that WPS can significantly affect specific cardiac parameters during the normal development of zebrafish. Further investigations are necessary to elucidate the pathogenic outcome of WPS on different aspects of human life, including pregnancy.

Indexed as

Water Pipe SmokingZebrafishAnimalsFemaleHeartHumansMiddle EastNatriuretic Peptide, BrainPregnancyNatriuretic Peptide, Braindevelopmental biologytoxicity testingwaterpipe smokingzebrafish

Identifiers

PMID34770174

DOI10.3390/ijerph182111659

PMCPMC8582815

OpenAlexW3213771553

What OpenQuestion holds

Textmetadata

LicenceCC BY

Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.