Observational studyInternational journal of environmental research and public health2021
Role of SatO2, PaO2/FiO2 Ratio and PaO2 to Predict Adverse Outcome in COVID-19: A Retrospective, Cohort Study.
Observational study in International journal of environmental research and public health, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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21 citing papers in PubMed, 47 citations in OpenAlex.
- Impact of ventilatory and laboratory parameter trajectories on short-term survival in acute respiratory distress syndrome patients: a retrospective study using joint models.European journal of medical research · 2025Article
- Evaluating the impact of ESICM 2023 guidelines and the new global definition of ARDS on clinical outcomes: insights from MIMIC-IV cohort data.European journal of medical research · 2025Article
- Predictive modelling and identification of critical variables of mortality risk in COVID-19 patients.Scientific reports · 2025Article
- High-Dose Corticosteroids in Critically Ill COVID-19 Patients: A Retrospective Cohort Study from Suriname.Journal of inflammation research · 2025Article
- Clinical Characteristics and Mortality Risk Factors in Patients with Tuberculosis and CoincidentInfection and drug resistance · 2025Article
- The SpOJournal of clinical medicine · 2024Article
- Estimation of outpatient SARS-CoV-2 reinfection and recurrence rates and associated factors among COVID-19 hospitalized patients over one-year old: a multicenter retrospective cohort study.BMC infectious diseases · 2024Article
- Performance of oxygenation indices and risk scores to predict invasive mechanical ventilation and mortality in COVID-19.BMC pulmonary medicine · 2024Article
- Association between (ΔPaO2/FiO2)/PEEP and in-hospital mortality in patients with COVID-19 pneumonia: A secondary analysis.PloS one · 2024Article
- Evaluation of d-dimer as outcome biomarker in COVID-19 acute respiratory distress patients.Revista do Instituto de Medicina Tropical de Sao Paulo · 2024Observational
- Single-center nomogram model for sepsis complicated by acute lung injury.American journal of translational research · 2024Article
- Prognostic value of respiratory parameters for COVID-19 patients in the emergency department: results from the EC-COVID study.Internal and emergency medicine · 2023Article
- Association between Older Age and Psychiatric Symptoms in a Population of Hospitalized Patients with COVID-19.Journal of personalized medicine · 2023Article
- Mechanical Ventilation in COVID-19 Patients: a question from Age to Frailty.Aging and disease · 2023Article
- Article
- Lactate dehydrogenase and PaO2/FiO2 ratio at admission helps to predict CT score in patients with COVID-19: An observational study.Journal of infection and public health · 2023Observational
- Extracting relevant predictive variables for COVID-19 severity prognosis: An exhaustive comparison of feature selection techniques.PloS one · 2023Article
- Article
- Role of fecal calprotectin as a hypoxic intestinal damage biomarker in COVID-19 patients.Gut pathogens · 2022Article
- Riding the COVID Waves: Clinical Trends, Outcomes, and Remaining Pitfalls of the SARS-CoV-2 Pandemic: An Analysis of Two High-Incidence Periods at a Hospital in Northern Italy.Journal of clinical medicine · 2021Article
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Authors and funding
12 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
COVID-19 respiratory failure is a life-threatening condition. Oxygenation targets were evaluated in a non-ICU setting. In this retrospective, observational study, we enrolled all patients admitted to the University Hospital of Genoa, Italy, between 1 February and 31 May 2020 with an RT-PCR positive for SARS-CoV-2. PaO2, PaO2/FiO2 and SatO2% were collected and analyzed at time 0 and in case of admission, patients who required or not C-PAP (groups A and B) were categorized. Each measurement was correlated to adverse outcome. A total of 483 patients were enrolled, and 369 were admitted to hospital. Of these, 153 required C-PAP and 266 had an adverse outcome. Patients with PaO2 <60 and >100 had a higher rate of adverse outcome at time 0, in groups A and B (OR 2.52, 3.45, 2.01, respectively). About the PaO2/FiO2 ratio, the OR for < 300 was 3.10 at time 0, 4.01 in group A and 4.79 in group B. Similar odds were found for < 200 in any groups and < 100 except for group B (OR 11.57). SatO2 < 94% showed OR 1.34, 3.52 and 19.12 at time 0, in groups A and B, respectively. PaO2 < 60 and >100, SatO2 < 94% and PaO2/FiO2 ratio < 300 showed at least two- to three-fold correlation to adverse outcome. This may provide simple but clear targets for clinicians facing COVID-19 respiratory failure in a non ICU-setting.
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