Evidence map›Paper›PMID 34769998›Full record

ArticleInternational journal of environmental research and public health2021

Association of

Alicja Zawiślak, Krzysztof Woźniak, Xabier Agirre, Satish Gupta, Beata Kawala, Anna Znamirowska-Bajowska, Katarzyna Grocholewicz, Jan Lubiński, Felipe Prosper, Anna Jakubowska

Open access · goldAbstract read
In one paragraph

Article in International journal of environmental research and public health, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
1.4field-weighted citation impact, top 17% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 10 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
  4. Single-Nucleotide Polymorphisms inDiagnostics (Basel, Switzerland) · 2024
    Article
  5. Article
  6. Article
  7. Open medicine (Warsaw, Poland) · 2023
    Article
  8. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 4 institutions in 2 countries.

Alicja ZawiślakDepartment of Interdisciplinary Dentistry, Pomeranian Medical University, 70-111 Szczecin, Poland.ORCID 0000-0003-2036-2853
Krzysztof WoźniakDepartment of Orthodontics, Pomeranian Medical University, 70-111 Szczecin, Poland.
Xabier AgirreCentro de Investigación Médica Aplicada, IDISNA, Universidad de Navarra, Avenida Pío XII-55, 31008 Pamplona, Spain.ORCID 0000-0002-6558-9560
Satish GuptaHereditary Cancer Center, Department of Genetics and Pathology, Pomeranian Medical University, 70-111 Szczecin, Poland.
Beata KawalaDepartment of Dentofacial Orthopaedics and Orthodontics, Wrocław Medical University, 50-425 Wrocław, Poland.
Anna Znamirowska-BajowskaDepartment of Dentofacial Orthopaedics and Orthodontics, Wrocław Medical University, 50-425 Wrocław, Poland.
Katarzyna GrocholewiczDepartment of Interdisciplinary Dentistry, Pomeranian Medical University, 70-111 Szczecin, Poland.ORCID 0000-0002-1468-4664
Jan LubińskiHereditary Cancer Center, Department of Genetics and Pathology, Pomeranian Medical University, 70-111 Szczecin, Poland.ORCID 0000-0003-2931-3003
Felipe ProsperCentro de Investigación Médica Aplicada, IDISNA, Universidad de Navarra, Avenida Pío XII-55, 31008 Pamplona, Spain.ORCID 0000-0001-6115-8790
Anna JakubowskaHereditary Cancer Center, Department of Genetics and Pathology, Pomeranian Medical University, 70-111 Szczecin, Poland.
International Hereditary Cancer Center · PLPomeranian Medical University · PLUniversidad de Navarra · ESWroclaw Medical University · PL

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundNon-syndromic cleft lip with/without cleft palate (NSCL/P) is a common congenital condition with a complex aetiology reflecting multiple genetic and environmental factors. Single nucleotide polymorphisms (SNPs) in

methodsThe study included 627 participants: 209 paediatric patients with NSCL/P and 418 healthy newborn controls. DNA was isolated from the saliva of NSCL/P patients and from umbilical cord blood in the controls. Genotyping of rs4147811 and rs560426 was performed using quantitative PCR.

resultsThe rs4147811 (AG genotype) SNP in LIMITATIONS: This study-based on the correlation between single genetic variants and the occurrence of different phenotypes-might have limited power in detecting relevant, complex inheritance patterns. ORs are often low to moderate when investigating the association of single genes with the risk of a complex trait. Another limitation was the small number of available NSCL/P samples.

conclusionsThe results suggest that genetic variations in

Indexed as

Cleft LipCleft PalateATP-Binding Cassette TransportersCase-Control StudiesChildGenetic Predisposition to DiseaseGenotypeHumansPolandPolymorphism, Single NucleotideABCA4 protein, humanATP-Binding Cassette TransportersABCA4cleft lipcleft palatecongenital conditiongenetic variationsingle nucleotide polymorphism

Identifiers

PMID34769998
PMCPMC8583664
OpenAlexW3211024819

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.