Evidence map›Paper›PMID 34769816›Full record

SynthesisInternational journal of environmental research and public health2021

Italian Expert Consensus on Clinical and Therapeutic Management of Multiple Chemical Sensitivity (MCS).

Giovanni Damiani, Marco Alessandrini, Daniela Caccamo, Andrea Cormano, Gianpaolo Guzzi, Andrea Mazzatenta, Alessandro Micarelli, Alberto Migliore, Alba Piroli, Margherita Bianca and 2 more

Open access · goldAbstract readSystematic ReviewConsensus Statement
In one paragraph

Synthesis in International journal of environmental research and public health, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.

0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed
3.5field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

18 citing papers in PubMed, 31 citations in OpenAlex.

  1. Article
  2. Prevalence of Multiple Chemical Sensitivity in Canada Between 2000 and 2020.International journal of environmental research and public health · 2026
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 8 institutions in 1 country.

Giovanni DamianiDepartment of Biomedical, Surgical and Dental Sciences, University of Milan, 20122 Milan, Italy.ORCID 0000-0002-2390-6505
Marco AlessandriniDepartment of Clinical Sciences and Translational Medicine, University of Rome Tor Vergata, 00133 Rome, Italy.
Daniela CaccamoDepartment of Biomedical Sciences, Dental Sciences, & Morpho-Functional Imaging, Polyclinic Hospital University, 98124 Messina, Italy.
Andrea CormanoInternational Society of Doctors for Environment, 82100 Benevento, Italy.ORCID 0000-0003-2096-706X
Gianpaolo GuzziItalian Association for Metals and Biocompatibility Research-A.I.R.M.E.B., 20122 Milan, Italy.
Andrea MazzatentaDepartment of Neuroscience, Imaging and Clinical Science, 'G. d'Annunzio' University of Chieti-Pescara, 66100 Chieti, Italy.ORCID 0000-0001-5132-0029
Alessandro MicarelliInstitute of Mountain Emergency Medicine, Eurac Research, 39100 Bolzano, Italy.
Alberto MiglioreDepartment of Internal Medicine, Unit of Rheumatology, San Pietro Fatebenefratelli Hospital, 00189 Rome, Italy.
Alba PiroliDepartment of MeSVA, University of L'Aquila, 67100 L'Aquila, Italy.ORCID 0000-0002-1722-6490
Margherita Bianca
Ottaviano TapparoNatrail Tagesklinik, 81925 Munchen, Germany.
Paolo Daniele Maria PigattoDepartment of Biomedical, Surgical and Dental Sciences, University of Milan, 20122 Milan, Italy.
Assocomaplast · ITEurac Research · ITFatebenefratelli Hospital · ITUniversity of Chieti-Pescara · ITUniversity of L'Aquila · ITUniversity of Milan · ITUniversity of Padua · ITUniversity of Rome Tor Vergata · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Multiple chemical sensitivity (MCS) is a multisystem, recurrent, environmental disorder that flares in response to different exposures (i.e., pesticides, solvents, toxic metals and molds) under the threshold limit value (TLV) calculated for age and gender in the general population. MCS is a syndrome characterized by cutaneous, allergic, gastrointestinal, rheumatological, endocrinological, cardiological and neurological signs and symptoms. We performed a systematic review of the literature to summarize the current clinical and therapeutic evidence and then oriented an eDelphi consensus. Four main research domains were identified (diagnosis, treatment, hospitalization and emergency) and discussed by 10 experts and an MCS patient. Thus, the first Italian MCS consensus had the double aim: (a) to improve MCS knowledge among healthcare workers and patients by standardizing the clinical and therapeutic management to MCS patients; and (b) to improve and shed light on MCS misconceptions not supported by evidence-based medicine (EBM).

Indexed as

HypersensitivityMultiple Chemical SensitivityConsensusHumansItalySolventsSolventschemical intoleranceenvironmental exposuremultiple chemical sensitivity (MCS)neurogenic inflammationthreshold limit value

Identifiers

PMID34769816
PMCPMC8582949
OpenAlexW3210668245

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.