Evidence map›Paper›PMID 34769711›Full record

ArticleInternational journal of environmental research and public health2021

Men Show Reduced Cardiac Baroreceptor Sensitivity during Modestly Painful Electrical Stimulation of the Forearm: Exploratory Results from a Sham-Controlled Crossover Vagus Nerve Stimulation Study.

Elisabeth Veiz, Susann-Kristin Kieslich, Julia Staab, Dirk Czesnik, Christoph Herrmann-Lingen, Thomas Meyer

Open access · goldAbstract readControlled Clinical Trial
In one paragraph

Article in International journal of environmental research and public health, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed, 1 pooled it
0.6field-weighted citation impact, top 29% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 1 synthesis or guideline pooled it, 5 citations in OpenAlex.

  1. Transcutaneous vagus nerve stimulation and exercise-induced autonomic regulation: a systematic review.Clinical autonomic research : official journal of the Clinical Autonomic Research Society · 2026
    Pooled it
  2. Trial
  3. Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Elisabeth VeizDepartment of Psychosomatic Medicine and Psychotherapy, University Medical Center, University of Göttingen, 37075 Göttingen, Germany.
Susann-Kristin KieslichDepartment of Psychosomatic Medicine and Psychotherapy, University Medical Center, University of Göttingen, 37075 Göttingen, Germany.
Julia StaabDepartment of Psychosomatic Medicine and Psychotherapy, University Medical Center, University of Göttingen, 37075 Göttingen, Germany.ORCID 0000-0002-7972-054X
Dirk CzesnikDepartment of Neurology, University Medical Center, University of Göttingen, 37075 Göttingen, Germany.
Christoph Herrmann-LingenDepartment of Psychosomatic Medicine and Psychotherapy, University Medical Center, University of Göttingen, 37075 Göttingen, Germany.
Thomas MeyerDepartment of Psychosomatic Medicine and Psychotherapy, University Medical Center, University of Göttingen, 37075 Göttingen, Germany.ORCID 0000-0003-3509-1400
German Centre for Cardiovascular Research · DEUniversity of Göttingen · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

This paper presents data from a transcutaneous vagus nerve stimulation experiment that point towards a blunted cardiac baroreceptor sensitivity (cBRS) in young males compared to females during electrical stimulation of the forearm and a rhythmic breathing task. Continuous electrocardiography, impedance cardiography and continuous blood-pressure recordings were assessed in a sex-matched cohort of twenty young healthy subjects. Electrical stimulation of the median nerve was conducted by using a threshold-tracking method combined with two rhythmic breathing tasks (0.1 and 0.2 Hz) before, during and after active or sham transcutaneous vagus nerve stimulation. Autonomic and hemodynamic parameters were calculated, and differences were analyzed by using linear mixed models and post hoc F-tests. None of the autonomic and hemodynamic parameters differed between the sham and active conditions. However, compared to females, male participants had an overall lower total cBRS independent of stimulation condition during nerve stimulation (females: 14.96 ± 5.67 ms/mmHg, males: 11.89 ± 3.24 ms/mmHg,

Indexed as

Vagus Nerve StimulationCross-Over StudiesElectric StimulationFemaleForearmHeart RateHumansMalePressoreceptorsVagus Nerveheart rate variabilitynerve stimulationsex differencesspontaneous baroreceptor sensitivitystresstranscutaneous vagus nerve stimulation

Identifiers

PMID34769711
PMCPMC8582936
OpenAlexW3210381953

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.