Evidence map›Paper›PMID 34769513›Full record

ArticleInternational journal of molecular sciences2021

Glycation of Host Proteins Increases Pathogenic Potential of

Michał Śmiga, John W Smalley, Paulina Ślęzak, Jason L Brown, Klaudia Siemińska, Rosalind E Jenkins, Edwin A Yates, Teresa Olczak

Open access · goldAbstract read
In one paragraph

Article in International journal of molecular sciences, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed
3.5field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed, 29 citations in OpenAlex.

  1. Review
  2. Review
  3. Article
  4. Article
  5. Article
  6. Review
  7. Review
  8. Article
  9. Review
  10. Review
  11. Comparative analysis ofMicrobiology spectrum · 2024
    Article
  12. Frontiers in cellular and infection microbiology · 2024
    Article
  13. Article
  14. Unique Properties of Heme Binding of theMolecules (Basel, Switzerland) · 2022
    Article
  15. Review
  16. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 2 countries.

Michał ŚmigaLaboratory of Medical Biology, Faculty of Biotechnology, University of Wrocław, 14A F. Joliot-Curie St., 50-383 Wrocław, Poland.ORCID 0000-0002-9236-4236
John W SmalleyInstitute of Life Course and Medical Sciences, School of Dentistry, The University of Liverpool, Pembroke Place, Liverpool L3 5PS, UK.
Paulina ŚlęzakLaboratory of Medical Biology, Faculty of Biotechnology, University of Wrocław, 14A F. Joliot-Curie St., 50-383 Wrocław, Poland.
Jason L BrownInstitute of Life Course and Medical Sciences, School of Dentistry, The University of Liverpool, Pembroke Place, Liverpool L3 5PS, UK.ORCID 0000-0002-8168-5333
Klaudia SiemińskaLaboratory of Medical Biology, Faculty of Biotechnology, University of Wrocław, 14A F. Joliot-Curie St., 50-383 Wrocław, Poland.ORCID 0000-0002-8556-4424
Rosalind E JenkinsCDSS Bioanalytical Facility, Department of Pharmacology and Therapeutics, Institute of Systems, Molecular and Integrative Biology, Faculty of Health and Life Science, The University of Liverpool, Liverpool L69 3GE, UK.ORCID 0000-0002-3730-1136
Edwin A YatesInstitute of Systems, Molecular and Integrative Biology, Faculty of Health and Life Science, The University of Liverpool, Liverpool L69 7ZB, UK.
Teresa OlczakLaboratory of Medical Biology, Faculty of Biotechnology, University of Wrocław, 14A F. Joliot-Curie St., 50-383 Wrocław, Poland.ORCID 0000-0002-6140-8144
University of Liverpool · GBUniversity of Wrocław · PL

Funding

National Science Center 2016/23/B/NZ6/00080
6 · The paper itself

Abstract

The non-enzymatic addition of glucose (glycation) to circulatory and tissue proteins is a ubiquitous pathophysiological consequence of hyperglycemia in diabetes. Given the high incidence of periodontitis and diabetes and the emerging link between these conditions, it is of crucial importance to define the basic virulence mechanisms employed by periodontopathogens such as

Indexed as

AnimalsBacteroidaceae InfectionsDiabetes ComplicationsErythrocytesGlycosylationHemeHemeproteinsHemoglobinsHorsesPeriodontitisPorphyromonas gingivalisHemeHemeproteinsHemoglobinsalbumincollagendiabetesglycationhemehemoglobinHmuYpathogenesisperiodontitisPorphyromonas gingivalis

Identifiers

PMID34769513
PMCPMC8585099
OpenAlexW3212244848

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.