Evidence map›Paper›PMID 34769482›Full record

ArticleInternational journal of molecular sciences2021

The Anti-Inflammatory Effect of Hydrogen Gas Inhalation and Its Influence on Laser-Induced Choroidal Neovascularization in a Mouse Model of Neovascular Age-Related Macular Degeneration.

I-Chia Liang, Wen-Chin Ko, Yu-Jou Hsu, Yi-Ru Lin, Yun-Hsiang Chang, Xv-Hui Zong, Pei-Chen Lai, Der-Chen Chang, Chi-Feng Hung

Open access · goldAbstract read
In one paragraph

Article in International journal of molecular sciences, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
2.1field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 13 citations in OpenAlex.

  1. Article
  2. Article
  3. Novel Role of Molecular Hydrogen: The End of Ophthalmic Diseases?Pharmaceuticals (Basel, Switzerland) · 2023
    Review
  4. Article
  5. Review
  6. Multimodal imaging of experimental choroidal neovascularization.International journal of ophthalmology · 2022
    Article
  7. High Mobility Group Proteins in Sepsis.Frontiers in immunology · 2022
    Review
  8. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 5 institutions in 2 countries.

I-Chia LiangDepartment of Ophthalmology, Tri-Service General Hospital, National Defense Medical Center, Taipei 11490, Taiwan.ORCID 0000-0001-9554-1114
Wen-Chin KoSchool of Medicine, Fu Jen Catholic University, New Taipei City 24205, Taiwan.
Yu-Jou HsuGraduate Institute of Biomedical and Pharmaceutical Science, Fu Jen Catholic University, New Taipei City 24205, Taiwan.
Yi-Ru LinDepartment of Ophthalmology, Cathay General Hospital, Taipei 10630, Taiwan.
Yun-Hsiang ChangDepartment of Ophthalmology, Tri-Service General Hospital, National Defense Medical Center, Taipei 11490, Taiwan.
Xv-Hui ZongTsung Cho Chang Laboratory, College of Medicine, Fu-Jen Catholic University, New Taipei City 24205, Taiwan.
Pei-Chen LaiInstitute of Biochemistry and Molecular Biology, College of Medicine, National Taiwan University, Taipei 100233, Taiwan.
Der-Chen ChangDepartment of Mathematics and Statistics and Department of Computer Science, Georgetown University, Washington, DC 20057, USA.
Chi-Feng HungSchool of Medicine, Fu Jen Catholic University, New Taipei City 24205, Taiwan.ORCID 0000-0003-3478-5451
Fu Jen Catholic University · TWCathay General Hospital · TWGeorgetown University · USNational Taiwan University · TWTri-Service General Hospital · TW

Funding

Cathay General Hospital 109-CGH-FJU-03Ministry of Science and Technology in Taiwan MOST110-2320-B-030-004-MY
6 · The paper itself

Abstract

backgroundAge-related macular degeneration (AMD) is a leading cause of blindness in the elderly. Choroidal neovascularization (CNV) is the major pathologic feature of neovascular AMD. Oxidative damages and the ensuing chronic inflammation are representative of trigger events. Hydrogen gas (H

methodsLaser was used to induce CNV formation. C57BL/6J mice were divided into five groups: the control group; the laser-only group; and the 2 h, 5 h, and 2.5 h/2.5 h groups that received laser and H

resultsThe severity of CNV leakage on fluorescence angiography showed a significant decrease in the H

conclusionH

Indexed as

Administration, InhalationAngiogenesis InhibitorsAnimalsAnti-Inflammatory AgentsChoroidal NeovascularizationDisease Models, AnimalFluorescein AngiographyFundus OculiGasesHydrogenLasersMacular DegenerationMiceMice, Inbred C57BLWet Macular DegenerationAngiogenesis InhibitorsAnti-Inflammatory AgentsGasesHydrogenage-related macular degenerationchoroidal neovascularizationhydrogen gas

Identifiers

PMID34769482
PMCPMC8584469
OpenAlexW3214169832

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.