Expression of Human Mutant Preproinsulins Induced Unfolded Protein Response,

Tatsuki Yamazoe, Yasuyuki Nakahara, Hiroka Katsube, Yoshihiro H Inoue

Open access · goldAbstract read

In one paragraph

Article in International journal of molecular sciences, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it

0cells of the map it votes in

3citing papers in PubMed

0.1field-weighted citation impact, top 55% of its field

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 4 citations in OpenAlex.

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Review
Loss of Paip1 causes translation reduction and induces apoptotic cell death through ISR activation and Xrp1.Cell death discovery · 2023
Article

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Tatsuki YamazoeDepartment of Insect Biomedical Research, Kyoto Institute of Technology, Matsugasaki, Kyoto 606-0962, Sakyo, Japan.

Yasuyuki NakaharaDepartment of Insect Biomedical Research, Kyoto Institute of Technology, Matsugasaki, Kyoto 606-0962, Sakyo, Japan.

Hiroka KatsubeDepartment of Insect Biomedical Research, Kyoto Institute of Technology, Matsugasaki, Kyoto 606-0962, Sakyo, Japan.

Yoshihiro H InoueDepartment of Insect Biomedical Research, Kyoto Institute of Technology, Matsugasaki, Kyoto 606-0962, Sakyo, Japan.ORCID 0000-0002-0233-6726

Kyoto Institute of Technology · JP

Funding

Japan Society for the Promotion of Science Grant-in-Aid for Scientific Research C17K06277

6 · The paper itself

Abstract

Mutations in the insulin gene (INS) are frequently associated with human permanent neonatal diabetes mellitus. However, the mechanisms underlying the onset of this genetic disease is not sufficiently decoded. We induced expression of two types of human mutant INSs in

Indexed as

Unfolded Protein ResponseAnimalsAnimals, Genetically ModifiedDown-RegulationDrosophilaEmbryo, NonmammalianGADD45 ProteinsGrowth and DevelopmentHumansInsulinIntracellular Signaling Peptides and ProteinsJanus KinasesMutant ProteinsProtein PrecursorsSignal TransductionSTAT Transcription FactorsGADD45 ProteinsInsulinIntracellular Signaling Peptides and ProteinsJanus KinasesMutant ProteinspreproinsulinProtein PrecursorsSTAT Transcription FactorsdiabetesDrosophilaER stressGadd45JNKNDM

Identifiers

PMID34769468

DOI10.3390/ijms222112038

PMCPMC8584581

OpenAlexW3213812827

What OpenQuestion holds

Textmetadata

LicenceCC BY

Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.