Evidence map›Paper›PMID 34769458›Full record

ArticleInternational journal of molecular sciences2021

Cationic Peptides and Their Cu(II) and Ni(II) Complexes: Coordination and Biological Characteristics.

Aleksandra Kotynia, Benita Wiatrak, Wojciech Kamysz, Damian Neubauer, Paulina Jawień, Aleksandra Marciniak

Open access · goldAbstract read
In one paragraph

Article in International journal of molecular sciences, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
1.3field-weighted citation impact, top 21% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 14 citations in OpenAlex.

  1. Article
  2. Impact of the spatial distribution of positive charges on the catalytic activity of NiSOD bioinspired complexes.Journal of biological inorganic chemistry : JBIC : a publication of the Society of Biological Inorganic Chemistry · 2026
    Article
  3. Article
  4. Article
  5. Article
  6. Preparation, Characterization, and In Vitro Bioactivity ofInternational journal of food science · 2025
    Article
  7. Article
  8. Bioactive Peptides in Human Health and Disease.International journal of molecular sciences · 2023
    Article
  9. Interaction of Positively Charged Oligopeptides with Blood Plasma Proteins.International journal of molecular sciences · 2023
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 3 institutions in 1 country.

Aleksandra KotyniaDepartment of Inorganic Chemistry, Wroclaw Medical University, Borowska 211A, 50-556 Wroclaw, Poland.
Benita WiatrakDepartment of Pharmacology, Wroclaw Medical University, Jana Mikulicza-Radeckiego 2, 50-345 Wroclaw, Poland.ORCID 0000-0002-1404-2274
Wojciech KamyszDepartment of Inorganic Chemistry, Medical University of Gdańsk, Gen. J. Hallera 107, 80-416 Gdańsk, Poland.
Damian NeubauerDepartment of Inorganic Chemistry, Medical University of Gdańsk, Gen. J. Hallera 107, 80-416 Gdańsk, Poland.ORCID 0000-0002-3230-6878
Paulina JawieńDepartment of Pharmacology, Wroclaw Medical University, Jana Mikulicza-Radeckiego 2, 50-345 Wroclaw, Poland.
Aleksandra MarciniakDepartment of Inorganic Chemistry, Wroclaw Medical University, Borowska 211A, 50-556 Wroclaw, Poland.ORCID 0000-0003-2225-7897
Wroclaw Medical University · PLGdańsk Medical University · PLWrocław University of Environmental and Life Sciences · PL

Funding

Wrocław Medical University STM.D080.20.2020
6 · The paper itself

Abstract

Antimicrobial peptides are a promising group of compounds used for the treatment of infections. In some cases, metal ions are essential to activate these molecules. Examples of metalloantibiotics are, for instance, bleomycin and dermcidin. This study is focused on three new pseudopeptides with potential biological activity. The coordination behavior of all ligands with Cu(II) and Ni(II) ions has been examined. Various analytical methods such as potentiometric titration, UV-Vis and CD spectroscopies, and mass spectrometry were used. All compounds are convenient chelators for metal ion-binding. Two of the ligands tested have histidine residues. Surprisingly, imidazole nitrogen is not involved in the coordination of the metal ion. The

Indexed as

Antimicrobial PeptidesCationsCells, CulturedCoordination ComplexesCopperInflammationLigandsMolecular StructureNickelPeptidesAntimicrobial PeptidesCationsCoordination ComplexesCopperLigandsNickelPeptidesanti-inflammatorycationic peptidesCu(II) complexesLPS-neutralizationNi(II) complexespotentiometric titrationspectroscopic methods

Identifiers

PMID34769458
PMCPMC8584440
OpenAlexW3211479407

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.