Evidence map›Paper›PMID 34769392›Full record

ReviewInternational journal of molecular sciences2021

Aberrant Post-Transcriptional Regulation of Protein Expression in the Development of Chronic Obstructive Pulmonary Disease.

Noof Aloufi, Aeshah Alluli, David H Eidelman, Carolyn J Baglole

Open access · goldAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in International journal of molecular sciences, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.3field-weighted citation impact, top 49% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 5 citations in OpenAlex.

  1. Article
  2. Article
  3. Review
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 2 countries.

Noof AloufiDepartment of Pathology, McGill University, Montreal, QC H3A 2B4, Canada.
Aeshah AlluliDepartment of Pathology, McGill University, Montreal, QC H3A 2B4, Canada.
David H EidelmanDepartment of Medicine, McGill University, Montreal, QC H4A 3J1, Canada.
Carolyn J BagloleDepartment of Pathology, McGill University, Montreal, QC H3A 2B4, Canada.ORCID 0000-0002-3107-0437
McGill University · CATaibah University · SA

Funding

CIHR 162273CIHR 168836Natural Sciences and Engineering Research Council 04462
6 · The paper itself

Abstract

Chronic obstructive pulmonary disease (COPD) is an incurable and prevalent respiratory disorder that is characterized by chronic inflammation and emphysema. COPD is primarily caused by cigarette smoke (CS). CS alters numerous cellular processes, including the post-transcriptional regulation of mRNAs. The identification of RNA-binding proteins (RBPs), microRNAs (miRNAs), and long non-coding RNAs (lncRNAs) as main factors engaged in the regulation of RNA biology opens the door to understanding their role in coordinating physiological cellular processes. Dysregulation of post-transcriptional regulation by foreign particles in CS may lead to the development of diseases such as COPD. Here we review current knowledge about post-transcriptional events that may be involved in the pathogenesis of COPD.

Indexed as

Gene Expression RegulationRNA Processing, Post-TranscriptionalAnimalsHumansPulmonary Disease, Chronic ObstructiveCOPDmiRNAspost-transcriptional regulationRNA binding proteins

Identifiers

PMID34769392
PMCPMC8584689
OpenAlexW3214187420

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.