Evidence map›Paper›PMID 34769322›Full record

ArticleInternational journal of molecular sciences2021

Necroptosis Inhibition by Hydrogen Sulfide Alleviated Hypoxia-Induced Cardiac Fibroblasts Proliferation via Sirtuin 3.

Yue Zhang, Weiwei Gong, Mengting Xu, Shuping Zhang, Jieru Shen, Mingxian Zhu, Yuqin Wang, Yun Chen, Jiahai Shi, Guoliang Meng

Open access · goldAbstract read
In one paragraph

Article in International journal of molecular sciences, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
2.3field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 26 citations in OpenAlex.

  1. Review
  2. Cells · 2026
    Article
  3. Review
  4. Review
  5. Recent advances in the role of gasotransmitters in necroptosis.Apoptosis : an international journal on programmed cell death · 2025
    Review
  6. Article
  7. Review
  8. Review
  9. Review
  10. Targeting necroptosis in fibrosis.Molecular biology reports · 2023
    Review
  11. SIRT3 Is a Critical Regulator of Mitochondrial Function of Fibroblasts in Pulmonary Hypertension.American journal of respiratory cell and molecular biology · 2023
    Article
  12. Article
  13. Hydrogen Sulfide Suppresses Skin Fibroblast ProliferationOxidative medicine and cellular longevity · 2022
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 1 institution in 1 country.

Yue ZhangDepartment of Pharmacology, School of Pharmacy, Nantong University, Nantong 226001, China.
Weiwei GongDepartment of Pharmacology, School of Pharmacy, Nantong University, Nantong 226001, China.
Mengting XuDepartment of Pharmacology, School of Pharmacy, Nantong University, Nantong 226001, China.
Shuping ZhangDepartment of Pharmacology, School of Pharmacy, Nantong University, Nantong 226001, China.
Jieru ShenDepartment of Pharmacology, School of Pharmacy, Nantong University, Nantong 226001, China.
Mingxian ZhuDepartment of Pharmacology, School of Pharmacy, Nantong University, Nantong 226001, China.
Yuqin WangDepartment of Pharmacology, School of Pharmacy, Nantong University, Nantong 226001, China.
Yun ChenDepartment of Pharmacology, School of Pharmacy, Nantong University, Nantong 226001, China.
Jiahai ShiNantong Key Laboratory of Translational Medicine in Cardiothoracic Diseases, Research Institution of Translational Medicine in Cardiothoracic Diseases, Nantong University, Nantong 226001, China.
Guoliang MengDepartment of Pharmacology, School of Pharmacy, Nantong University, Nantong 226001, China.ORCID 0000-0002-8523-6543
Nantong University · CN

Funding

a major project of Natural Science Research in Jiangsu Higher Education Institutions 18KJA310005a Science and Technology Project of Nantong City MS22020006a Science and Technology Project of Taicang City TC2019KJFZ02Clinical Medical Research Center of Cardiothoracic Diseases in Nantong HS2019001Innovation Team of Cardiothoracic Disease in Nantong University TECT-A04Nantong Key Laboratory of Translational Medicine of Cardiothoracic DiseasesNational Natural Science Foundation of China 81770279, 82070280, 81770266the Six Talent Peaks Project in Jiangsu Province 2018-WSN-062
6 · The paper itself

Abstract

Myocardial ischemia or hypoxia can induce myocardial fibroblast proliferation and myocardial fibrosis. Hydrogen sulfide (H

Indexed as

NecroptosisAnimalsAnimals, NewbornCell ProliferationFibroblastsFibrosisGasotransmittersHeartHydrogen SulfideHypoxiaOxidative StressRatsRats, Sprague-DawleySirtuinsGasotransmittersHydrogen SulfideSIRT3 protein, ratSirtuinscardiac fibroblastshydrogen sulfidehypoxiaoxidative stresssirtuin 3

Identifiers

PMID34769322
PMCPMC8584899
OpenAlexW3209682353

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.