Evidence map›Paper›PMID 34769267›Full record

ArticleInternational journal of molecular sciences2021

CRISPRi-Guided Metabolic Flux Engineering for Enhanced Protopanaxadiol Production in

Soo-Hwan Lim, Jong-In Baek, Byeong-Min Jeon, Jung-Woo Seo, Min-Sung Kim, Ji-Young Byun, Soo-Hoon Park, Su-Jin Kim, Ju-Young Lee, Jun-Hyoung Lee and 1 more

Open access · goldAbstract read
In one paragraph

Article in International journal of molecular sciences, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
1.0field-weighted citation impact, top 25% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 20 citations in OpenAlex.

  1. Review
  2. Article
  3. Review
  4. Review
  5. Promoting Photosynthetic Production of Dammarenediol-II inInternational journal of molecular sciences · 2023
    Article
  6. Review
  7. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 2 institutions in 1 country.

Soo-Hwan LimIntelligent Synthetic Biology Center, 291 Daehak-ro, Daejeon 305-701, Korea.
Jong-In BaekDepartment of Biological Sciences, Korea Advanced Institute of Science and Technology, 291 Daehak-ro, Daejeon 305-701, Korea.ORCID 0000-0002-8742-5604
Byeong-Min JeonDepartment of Biological Sciences, Korea Advanced Institute of Science and Technology, 291 Daehak-ro, Daejeon 305-701, Korea.ORCID 0000-0002-5677-2806
Jung-Woo SeoIntelligent Synthetic Biology Center, 291 Daehak-ro, Daejeon 305-701, Korea.
Min-Sung KimDepartment of Biological Sciences, Korea Advanced Institute of Science and Technology, 291 Daehak-ro, Daejeon 305-701, Korea.
Ji-Young ByunDepartment of Biological Sciences, Korea Advanced Institute of Science and Technology, 291 Daehak-ro, Daejeon 305-701, Korea.
Soo-Hoon ParkIntelligent Synthetic Biology Center, 291 Daehak-ro, Daejeon 305-701, Korea.
Su-Jin KimIntelligent Synthetic Biology Center, 291 Daehak-ro, Daejeon 305-701, Korea.
Ju-Young LeeResearch Center for Bio-Based Chemistry, Korea Research Institute of Chemical Technology (KRICT), 406-30, Jongga-ro, Ulsan 44429, Korea.
Jun-Hyoung LeeIntelligent Synthetic Biology Center, 291 Daehak-ro, Daejeon 305-701, Korea.
Sun-Chang KimIntelligent Synthetic Biology Center, 291 Daehak-ro, Daejeon 305-701, Korea.
Korea Advanced Institute of Science and Technology · KRIntelligent Synthetic Biology Center · KR

Funding

Advancement of Active Biomedical material Project P0014633Bio-Synergy Research Project NRF-2021M3A9C4001028Development of industrialization technology for crop virus and pest Project 321109041SB010Intelligent Synthetic Biology Center of the Global Frontier Project 2011-0031955
6 · The paper itself

Abstract

Protopanaxadiol (PPD), an aglycon found in several dammarene-type ginsenosides, has high potency as a pharmaceutical. Nevertheless, application of these ginsenosides has been limited because of the high production cost due to the rare content of PPD in

Indexed as

CRISPR-Cas SystemsMetabolic EngineeringMetabolic Networks and PathwaysSaccharomyces cerevisiaeSapogeninsprotopanaxadiolSapogeninsCRISPR interferenceginsenosideslanosterolmetabolic engineeringprotopanaxadiolSaccharomyces cerevisiaetriterpenes

Identifiers

PMID34769267
PMCPMC8584524
OpenAlexW3208070254

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.