Evidence map›Paper›PMID 34769256›Full record

ReviewInternational journal of molecular sciences2021

Fertility-Sparing Approach in Women Affected by Stage I and Low-Grade Endometrial Carcinoma: An Updated Overview.

Giuseppe Gullo, Andrea Etrusco, Gaspare Cucinella, Antonino Perino, Vito Chiantera, Antonio Simone Laganà, Rossella Tomaiuolo, Amerigo Vitagliano, Pierluigi Giampaolino, Marco Noventa and 2 more

Registry-linked trialAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in International journal of molecular sciences, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05823194 (The Evaluation of Infertility and Pregnancy Outcomes, as Well as the Assessment of Quality of Life Using WHOQoL and FertiQoL, in Cases of Gynecological Malignancies That Have Undergone Fertility-sparing Surgery), which is not on this map. Cited by 47 papers, 6 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
47citing papers in PubMed, 6 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT05823194 naunknown statusnot on this mapstarted 2022, after this paper: background citation

The Evaluation of Infertility and Pregnancy Outcomes, as Well as the Assessment of Quality of Life Using WHOQoL and FertiQoL, in Cases of Gynecological Malignancies That Have Undergone Fertility-sparing Surgery(FSS)

TypeinterventionalSponsorAcibadem UniversityRan2022 to 2023Enrolled50ConditionsFertility Disorders, Gynecologic CancerArmsFertility sparing surgery
3 · Its place in the literature

Who cites it

47 citing papers in PubMed, 6 syntheses or guidelines pooled it.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Giuseppe GulloDepartment of Obstetrics and Gynecology, Villa Sofia Cervello Hospital, IVF UNIT, University of Palermo, 90146 Palermo, Italy.ORCID 0000-0003-4269-4269
Andrea EtruscoDepartment of Obstetrics and Gynecology, Villa Sofia Cervello Hospital, University of Palermo, 90146 Palermo, Italy.
Gaspare CucinellaDepartment of Obstetrics and Gynecology, Villa Sofia Cervello Hospital, IVF UNIT, University of Palermo, 90146 Palermo, Italy.
Antonino PerinoDepartment of Obstetrics and Gynecology, Villa Sofia Cervello Hospital, IVF UNIT, University of Palermo, 90146 Palermo, Italy.
Vito ChianteraDepartment of Gynecology Oncology, University of Palermo, 90146 Palermo, Italy.
Antonio Simone LaganàDepartment of Obstetrics and Gynecology, "Filippo Del Ponte" Hospital, University of Insubria, 21100 Varese, Italy.ORCID 0000-0003-1543-2802
Rossella TomaiuoloVita-Salute San Raffaele University, 20132 Milan, Italy.ORCID 0000-0002-2828-782X
Amerigo VitaglianoDepartment of Women's and Children's Health, Gynaecological Clinic, University of Padova, 35128 Padova, Italy.ORCID 0000-0002-2824-5435
Pierluigi GiampaolinoDepartment of Public Health, University Federico II of Naples, 80138 Naples, Italy.
Marco NoventaDepartment of Women's and Children's Health, Gynaecological Clinic, University of Padova, 35128 Padova, Italy.
Alessandra AndrisaniDepartment of Women's and Children's Health, Gynaecological Clinic, University of Padova, 35128 Padova, Italy.
Giovanni BuzzaccariniDepartment of Women's and Children's Health, Gynaecological Clinic, University of Padova, 35128 Padova, Italy.ORCID 0000-0002-9466-0178

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Endometrial cancer (EC) is a deleterious condition which strongly affects a woman's quality of life. Although aggressive interventions should be considered to treat high-grade EC, a conservative approach should be taken into consideration for women wishing to conceive. In this scenario, we present an overview about the EC fertility-sparing approach state of art. Type I EC at low stage is the only histological type which can be addressed with a fertility-sparing approach. Moreover, no myometrium and/or adnexal invasion should be seen, and lymph-vascular space should not be involved. Regarding the pharmaceutical target, progestins, in particular medroxyprogesterone acetate (MPA) or megestrol acetate (MA), are the most employed agent in conservative treatment of early-stage EC. The metformin usage and hysteroscopic assessment is still under debate, despite promising results. Particularly strict and imperious attention should be given to the follow-up and psychological wellbeing of women, especially because of the double detrimental impairment: both EC and EC-related infertility consequences.

Indexed as

Fertility PreservationQuality of LifeAdultEndometrial NeoplasmsFemaleFertilityHumansMedroxyprogesterone AcetateMyometriumNeoplasm StagingProgestinsMedroxyprogesterone AcetateProgestinsARTendometrial cancerfertility preservationfertility sparinginfertilityIUDmetforminprogestin

Identifiers

PMID34769256
PMCPMC8583899

What OpenQuestion holds

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.