Evidence map›Paper›PMID 34769246›Full record

ArticleInternational journal of molecular sciences2021

SARS-CoV-2 Exposed Mesenchymal Stromal Cell from Congenital Pulmonary Airway Malformations: Transcriptomic Analysis and the Expression of Immunomodulatory Genes.

Andrea Valeri, Luigi Chiricosta, Agnese Gugliandolo, Mara Biasin, Maria Antonietta Avanzini, Valeria Calcaterra, Gioia Cappelletti, Stephana Carelli, Gian Vincenzo Zuccotti, Serena Silvestro and 2 more

Open access · goldAbstract read
In one paragraph

Article in International journal of molecular sciences, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.8field-weighted citation impact, top 26% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 5 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
  4. Development of an Active Training Method for Belt Conveyor.International journal of environmental research and public health · 2021
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 4 institutions in 1 country.

Andrea ValeriIRCCS Centro Neurolesi "Bonino-Pulejo", Via Provinciale Palermo, Contrada Casazza, 98124 Messina, Italy.ORCID 0000-0002-1457-1619
Luigi ChiricostaIRCCS Centro Neurolesi "Bonino-Pulejo", Via Provinciale Palermo, Contrada Casazza, 98124 Messina, Italy.ORCID 0000-0003-0358-7348
Agnese GugliandoloIRCCS Centro Neurolesi "Bonino-Pulejo", Via Provinciale Palermo, Contrada Casazza, 98124 Messina, Italy.ORCID 0000-0002-7868-3353
Mara BiasinDepartment of Biomedical and Clinical Sciences-L. Sacco, University of Milan, 20157 Milan, Italy.ORCID 0000-0003-3671-4235
Maria Antonietta AvanziniCell Factory, Pediatric Hematology Oncology Unit, Fondazione IRCCS Policlinico San Matteo, 27100 Pavia, Italy.ORCID 0000-0002-6056-9018
Valeria CalcaterraDepartment of Pediatrics, Children's Hospital "Vittore Buzzi", 20154 Milano, Italy.ORCID 0000-0002-2137-5974
Gioia CappellettiDepartment of Biomedical and Clinical Sciences-L. Sacco, University of Milan, 20157 Milan, Italy.ORCID 0000-0002-2932-2391
Stephana CarelliPediatric Clinical Research Center, Fondazione Romeo ed Enrica Invernizzi, University of Milan, 20157 Milan, Italy.ORCID 0000-0003-4603-396X
Gian Vincenzo ZuccottiDepartment of Biomedical and Clinical Sciences-L. Sacco, University of Milan, 20157 Milan, Italy.ORCID 0000-0002-2795-9874
Serena SilvestroIRCCS Centro Neurolesi "Bonino-Pulejo", Via Provinciale Palermo, Contrada Casazza, 98124 Messina, Italy.ORCID 0000-0003-3846-0785
Emanuela MazzonIRCCS Centro Neurolesi "Bonino-Pulejo", Via Provinciale Palermo, Contrada Casazza, 98124 Messina, Italy.
Gloria PelizzoDepartment of Biomedical and Clinical Sciences-L. Sacco, University of Milan, 20157 Milan, Italy.
Centro Neurolesi Bonino Pulejo · ITUniversity of Milan · ITPoliclinico San Matteo Fondazione · ITUniversity of Pavia · IT

Funding

Bando Regione Lombardia DG Welfare RL_DG-WEL20MBIAS_01Fondazione Cariplo CAR_EXT20MBIAS_01Fondo integrativo Speciale per la Ricerca Covid-19, Ministero dell'Università e della Ricerca FISR2020IP_02959Ministero della Salute Current Research Funds 2021
6 · The paper itself

Abstract

The inflammatory response plays a central role in the complications of congenital pulmonary airway malformations (CPAM) and severe coronavirus disease 2019 (COVID-19). The aim of this study was to evaluate the transcriptional changes induced by SARS-CoV-2 exposure in pediatric MSCs derived from pediatric lung (MSCs-lung) and CPAM tissues (MSCs-CPAM) in order to elucidate potential pathways involved in SARS-CoV-2 infection in a condition of exacerbated inflammatory response. MSCs-lung and MSCs-CPAM do not express angiotensin-converting enzyme 2 (

Indexed as

Respiratory System AbnormalitiesTranscriptomeCase-Control StudiesCells, CulturedCOVID-19Gene Expression ProfilingHost-Pathogen InteractionsHumansInfantLungMaleMesenchymal Stem CellsRNA-SeqSARS-CoV-2congenital pulmonary airway malformationsmesenchymal stromal cellSARS-CoV-2transcriptomic analysis

Identifiers

PMID34769246
PMCPMC8584055
OpenAlexW3208934579

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.