Evidence map›Paper›PMID 34769231›Full record

ArticleInternational journal of molecular sciences2021

Omega-3 Polyunsaturated Fatty Acid Attenuates Uremia-Induced Brain Damage in Mice.

Eun-Ji Kim, Young Rok Ham, Jin Ah Shin, Jin Young Jeong, Ki Ryang Na, Kang Wook Lee, Jwa-Jin Kim, Dae Eun Choi

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of molecular sciences, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
0.8field-weighted citation impact, top 30% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 8 citations in OpenAlex.

  1. Study on Nursing Effect of Psychological Intervention on Uremic Hemodialysis Patients.Computational and mathematical methods in medicine · 2022
    Trial
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 1 institution in 1 country.

Eun-Ji KimDepartment of Medical Science, Medical School, Chungnam National University, Daejeon 35015, Korea.
Young Rok HamDepartment of Nephrology, Medical School, Chungnam National University, Daejeon 35015, Korea.ORCID 0000-0001-9140-6900
Jin Ah ShinDepartment of Medical Science, Medical School, Chungnam National University, Daejeon 35015, Korea.
Jin Young JeongDepartment of Nephrology, Medical School, Chungnam National University, Daejeon 35015, Korea.
Ki Ryang NaDepartment of Nephrology, Medical School, Chungnam National University, Daejeon 35015, Korea.
Kang Wook LeeDepartment of Nephrology, Medical School, Chungnam National University, Daejeon 35015, Korea.
Jwa-Jin KimDepartment of Medical Science, Medical School, Chungnam National University, Daejeon 35015, Korea.
Dae Eun ChoiDepartment of Medical Science, Medical School, Chungnam National University, Daejeon 35015, Korea.ORCID 0000-0003-2870-3958
Chungnam National University · KR

Funding

Chungnam National University Hospital 2019 (to Y.R.H.)National Research Foundation of Korea NRF-2021R1G1A1013523
6 · The paper itself

Abstract

Although the cause of neurological disease in patients with chronic kidney disease (CKD) has not been completely identified yet, recent papers have identified accumulated uremic toxin as its main cause. Additionally, omega-3 polyunsaturated fatty acid (ω-3 PUFA) plays an important role in maintaining normal nerve function, but its protective effects against uremic toxin is unclear. The objective of this study was to identify brain damage caused by uremic toxicity and determine the protective effects of ω-3 PUFA against uremic toxin. We divided mice into the following groups: wild-type (wt) sham (

Indexed as

BrainBrain InjuriesUremiaAnimalsCell LineFatty Acids, Omega-3KidneyMaleMicePhosphatidylinositol 3-KinasesProto-Oncogene Proteins c-aktSignal TransductionFatty Acids, Omega-3Phosphatidylinositol 3-KinasesProto-Oncogene Proteins c-aktapoptosisbrain injuryindoxyl sulfateischemia-reperfusionPI(3)K-Akt signalinguremic toxinω3-PUFA

Identifiers

PMID34769231
PMCPMC8583921
OpenAlexW3209508183

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.