Evidence map›Paper›PMID 34769223›Full record

ArticleInternational journal of molecular sciences2021

Time-Dependent Image Restoration of Low-SNR Live-Cell Ca

Lena-Marie Woelk, Sukanya A Kannabiran, Valerie J Brock, Christine E Gee, Christian Lohr, Andreas H Guse, Björn-Philipp Diercks, René Werner

Abstract read
In one paragraph

Article in International journal of molecular sciences, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. T cell CaFrontiers in immunology · 2023
    Review
  2. DARTS: an open-source Python pipeline for CaFrontiers in immunology · 2023
    Article
  3. Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Lena-Marie WoelkDepartment of Computational Neuroscience, University Medical Center Hamburg-Eppendorf, 20246 Hamburg, Germany.
Sukanya A KannabiranDepartment of Biochemistry and Molecular Cell Biology, University Medical Center Hamburg-Eppendorf, 20246 Hamburg, Germany.
Valerie J BrockDepartment of Biochemistry and Molecular Cell Biology, University Medical Center Hamburg-Eppendorf, 20246 Hamburg, Germany.ORCID 0000-0001-5547-499X
Christine E GeeInstitute of Synaptic Physiology, University Medical Center Hamburg-Eppendorf, 20246 Hamburg, Germany.ORCID 0000-0003-0345-3665
Christian LohrDivision of Neurophysiology, Institute of Zoology, University of Hamburg, 20146 Hamburg, Germany.ORCID 0000-0001-6518-6422
Andreas H GuseDepartment of Biochemistry and Molecular Cell Biology, University Medical Center Hamburg-Eppendorf, 20246 Hamburg, Germany.
Björn-Philipp DiercksDepartment of Biochemistry and Molecular Cell Biology, University Medical Center Hamburg-Eppendorf, 20246 Hamburg, Germany.ORCID 0000-0002-6635-1706
René WernerDepartment of Computational Neuroscience, University Medical Center Hamburg-Eppendorf, 20246 Hamburg, Germany.ORCID 0000-0002-2296-3305

Funding

Deutsche Forschungsgemeinschaft 335447717
6 · The paper itself

Abstract

Live-cell Ca2+ fluorescence microscopy is a cornerstone of cellular signaling analysis and imaging. The demand for high spatial and temporal imaging resolution is, however, intrinsically linked to a low signal-to-noise ratio (SNR) of the acquired spatio-temporal image data, which impedes on the subsequent image analysis. Advanced deconvolution and image restoration algorithms can partly mitigate the corresponding problems but are usually defined only for

Indexed as

AlgorithmsCalcium SignalingImage Processing, Computer-AssistedModels, TheoreticalCalciumHumansJurkat CellsMicroscopy, FluorescenceSignal-To-Noise RatioCalciumCa2+ imagingdeconvolutionfluorescence microscopyimage restorationlive-cell imaginglow signal-to-noise ratio

Identifiers

PMID34769223
PMCPMC8583969

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.