Evidence map›Paper›PMID 34769216›Full record

ArticleInternational journal of molecular sciences2021

Exploring the Assembly of Resorc[4]arenes for the Construction of Supramolecular Nano-Aggregates.

Fabio Buonsenso, Francesca Ghirga, Isabella Romeo, Gabriella Siani, Serena Pilato, Deborah Quaglio, Marco Pierini, Bruno Botta, Andrea Calcaterra

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of molecular sciences, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.8field-weighted citation impact, top 32% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 7 citations in OpenAlex.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 1 country.

Fabio BuonsensoDepartment of Chemistry and Technology of Drugs, "Department of Excellence 2018-2022", Sapienza University of Rome, P. le Aldo Moro 5, 00185 Rome, Italy.ORCID 0000-0002-8586-6836
Francesca GhirgaDepartment of Chemistry and Technology of Drugs, "Department of Excellence 2018-2022", Sapienza University of Rome, P. le Aldo Moro 5, 00185 Rome, Italy.ORCID 0000-0002-5591-5190
Isabella RomeoDepartment of Chemistry and Technology of Drugs, "Department of Excellence 2018-2022", Sapienza University of Rome, P. le Aldo Moro 5, 00185 Rome, Italy.
Gabriella SianiDepartment of Pharmacy, University of Chieti "G. D'Annunzio", Via dei Vestini 31, 66013 Chieti, Italy.
Serena PilatoDepartment of Pharmacy, University of Chieti "G. D'Annunzio", Via dei Vestini 31, 66013 Chieti, Italy.ORCID 0000-0003-4971-6483
Deborah QuaglioDepartment of Chemistry and Technology of Drugs, "Department of Excellence 2018-2022", Sapienza University of Rome, P. le Aldo Moro 5, 00185 Rome, Italy.
Marco PieriniDepartment of Chemistry and Technology of Drugs, "Department of Excellence 2018-2022", Sapienza University of Rome, P. le Aldo Moro 5, 00185 Rome, Italy.ORCID 0000-0003-4030-8205
Bruno BottaDepartment of Chemistry and Technology of Drugs, "Department of Excellence 2018-2022", Sapienza University of Rome, P. le Aldo Moro 5, 00185 Rome, Italy.ORCID 0000-0001-8707-4333
Andrea CalcaterraDepartment of Chemistry and Technology of Drugs, "Department of Excellence 2018-2022", Sapienza University of Rome, P. le Aldo Moro 5, 00185 Rome, Italy.ORCID 0000-0001-7036-6620
Sapienza University of Rome · ITUniversity of Chieti-Pescara · ITItalian Institute of Technology · IT

Funding

Ministry of Education, Universities and Research ARS01_00432
6 · The paper itself

Abstract

Many biologically active compounds feature low solubility in aqueous media and, thus, poor bioavailability. The formation of the host-guest complex by using calixarene-based macrocycles (i.e., resorcinol-derived cyclic oligomers) with a good solubility profile can improve solubilization of hydrophobic drugs. Herein, we explore the ability of resorc[4]arenes to self-assemble in polar solutions, to form supramolecular aggregates, and to promote water-solubility of an isoflavone endowed with anti-cancer activity, namely Glabrescione B (GlaB). Accordingly, we synthesized several architectures featuring a different pattern of substitution on the upper rim including functional groups able to undergo acid dissociation (i.e., carboxyl and hydroxyl groups). The aggregation phenomenon of the amphiphilic resorc[4]arenes has been investigated in a THF/water solution by UV-visible spectroscopy, at different pH values. Based on their ionization properties, we demonstrated that the supramolecular assembly of resorc[4]arene-based systems can be modulated at given pH values, and thus promoting the solubility of GlaB.

Indexed as

CalixarenesChromonesHydrophobic and Hydrophilic InteractionsSolubilityWaterCalixarenesChromonesglabrescione BWaterGlabrescione Bresorc[4]arenessolubilizing agentssupramolecular assemblyUV-vis spectroscopy

Identifiers

PMID34769216
PMCPMC8584166
OpenAlexW3208559224

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.