Evidence map›Paper›PMID 34769209›Full record

ReviewInternational journal of molecular sciences2021

Tailored Systemic Therapy for Colorectal Cancer Liver Metastases.

Carolin Czauderna, Kim Luley, Nikolas von Bubnoff, Jens U Marquardt

Abstract readReview
In one paragraph

Review in International journal of molecular sciences, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed.

  1. Article
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  5. Review
  6. Article
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  10. Review
  11. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Carolin CzaudernaDepartment of Medicine I, University Medical Center Schleswig-Holstein-Campus Lübeck, 23558 Lübeck, Germany.ORCID 0000-0001-8451-8015
Kim LuleyDepartment of Hemato-Oncology, University Medical Center Schleswig-Holstein-Campus Lübeck, 23558 Lübeck, Germany.
Nikolas von BubnoffDepartment of Hemato-Oncology, University Medical Center Schleswig-Holstein-Campus Lübeck, 23558 Lübeck, Germany.ORCID 0000-0001-9593-8947
Jens U MarquardtDepartment of Medicine I, University Medical Center Schleswig-Holstein-Campus Lübeck, 23558 Lübeck, Germany.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Liver metastases are the most common site of metastatic spread in colorectal cancer. Current treatment approaches involve effective systemic therapies in combination with surgical and/or interventional strategies. Multimodal strategies greatly improved clinical outcomes of patients with metastatic colorectal cancer over the last decades. Identification of predictive and prognostic biomarkers helped to comprehensively refine individual targeted treatment approaches and resulted in median overall survival rates of 30 months or longer. Current guidelines, thus, recommend treatment selection according to patients' performance status, tumor localization and stage as well as the tumor's molecular and genetic status. Here, we outline the latest developments in molecular decision-making for patients with upfront resectable, potentially or initially unresectable and non/never-resectable colorectal cancer liver metastases.

Indexed as

AnimalsAntineoplastic Combined Chemotherapy ProtocolsColorectal NeoplasmsDisease ManagementHumansImmune Checkpoint InhibitorsLiverLiver NeoplasmsPrognosisImmune Checkpoint Inhibitorscolorectal cancermolecular biomarkerspredictionprognosis

Identifiers

PMID34769209
PMCPMC8584068

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.