ArticleInternational journal of molecular sciences2021
Enhancing the Efficiency of Distraction Osteogenesis through Rate-Varying Distraction: A Computational Study.
Article in International journal of molecular sciences, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers, 1 of them a synthesis that pooled it.
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Who cites it
7 citing papers in PubMed, 1 synthesis or guideline pooled it, 16 citations in OpenAlex.
- Masquelet's induced membrane technique in the upper limb: a systematic review of the current outcomes.Journal of orthopaedics and traumatology : official journal of the Italian Society of Orthopaedics and Traumatology · 2025Pooled it
- Radiological Analysis of Bone Regeneration in Different Tibial Distraction Osteogenesis Zones and Parts.Clinics in orthopedic surgery · 2026Article
- [Application and research progress of mandibular distraction osteogenesis in craniofacial microsomia].Zhongguo xiu fu chong jian wai ke za zhi = Zhongguo xiufu chongjian waike zazhi = Chinese journal of reparative and reconstructive surgery · 2026Review
- Finite element analysis safety of tibial cortex transverse transport.Bone & joint research · 2025Article
- Progress in immunoregulatory mechanisms during distraction osteogenesis.Frontiers in bioengineering and biotechnology · 2025Review
- Finite element analysis of biomechanical effects in rat tibia during tibial cortex transverse transport.Frontiers in bioengineering and biotechnology · 2025Article
- Zinc-Based Biodegradable Materials for Orthopaedic Internal Fixation.Journal of functional biomaterials · 2022Review
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Authors and funding
7 authors at 2 institutions in 2 countries.
Funding
Abstract
Distraction osteogenesis (DO) is a mechanobiological process of producing new bone and overlying soft tissues through the gradual and controlled distraction of surgically separated bone segments. The process of bone regeneration during DO is largely affected by distraction parameters. In the present study, a distraction strategy with varying distraction rates (i.e., "rate-varying distraction") is proposed, with the aim of shortening the distraction time and improving the efficiency of DO. We hypothesized that faster and better healing can be achieved with rate-varying distractions, as compared with constant-rate distractions. A computational model incorporating the viscoelastic behaviors of the callus tissues and the mechano-regulatory tissue differentiation laws was developed and validated to predict the bone regeneration process during DO. The effect of rate-varying distraction on the healing outcomes (bony bridging time and bone formation) was examined. Compared to the constant low-rate distraction, a low-to-high rate-varying distraction provided a favorable mechanical environment for angiogenesis and bone tissue differentiation, throughout the distraction and consolidation phase, leading to an improved healing outcome with a shortened healing time. These results suggest that a rate-varying clinical strategy could reduce the overall treatment time of DO and decrease the risk of complications related to the external fixator.
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Registered trials
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