Evidence map›Paper›PMID 34769113›Full record

ArticleInternational journal of molecular sciences2021

Novel Hybrid Peptide Cathelicidin 2 (1-13)-Thymopentin (TP5) and Its Derived Peptides with Effective Antibacterial, Antibiofilm, and Anti-Adhesion Activities.

He-Nan Guo, Yu-Cui Tong, Hui-Li Wang, Jing Zhang, Zhong-Xuan Li, Zaheer Abbas, Tian-Tian Yang, Meng-Yao Liu, Pei-Yao Chen, Zheng-Chang Hua and 8 more

Open access · goldAbstract read
In one paragraph

Article in International journal of molecular sciences, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
1.1field-weighted citation impact, top 23% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 11 citations in OpenAlex.

  1. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

18 authors at 5 institutions in 1 country.

He-Nan GuoLaboratory of Feed Biotechnology, State Key Laboratory of Animal Nutrition, College of Animal Science and Technology, China Agricultural University, Beijing 100193, China.
Yu-Cui TongLaboratory of Feed Biotechnology, State Key Laboratory of Animal Nutrition, College of Animal Science and Technology, China Agricultural University, Beijing 100193, China.
Hui-Li WangLaboratory of Feed Biotechnology, State Key Laboratory of Animal Nutrition, College of Animal Science and Technology, China Agricultural University, Beijing 100193, China.
Jing ZhangLaboratory of Feed Biotechnology, State Key Laboratory of Animal Nutrition, College of Animal Science and Technology, China Agricultural University, Beijing 100193, China.
Zhong-Xuan LiCollege of Bioengineering, Sichuan University of Science & Engineering, Zigong 643000, China.
Zaheer AbbasLaboratory of Feed Biotechnology, State Key Laboratory of Animal Nutrition, College of Animal Science and Technology, China Agricultural University, Beijing 100193, China.ORCID 0000-0002-0865-7192
Tian-Tian YangLaboratory of Feed Biotechnology, State Key Laboratory of Animal Nutrition, College of Animal Science and Technology, China Agricultural University, Beijing 100193, China.
Meng-Yao LiuLaboratory of Feed Biotechnology, State Key Laboratory of Animal Nutrition, College of Animal Science and Technology, China Agricultural University, Beijing 100193, China.
Pei-Yao ChenLaboratory of Feed Biotechnology, State Key Laboratory of Animal Nutrition, College of Animal Science and Technology, China Agricultural University, Beijing 100193, China.
Zheng-Chang HuaLaboratory of Feed Biotechnology, State Key Laboratory of Animal Nutrition, College of Animal Science and Technology, China Agricultural University, Beijing 100193, China.
Xiao-Na YanCollege of Animal Science and Technology, Hebei Normal University of Science & Technology, Qinhuangdao 066004, China.
Qiang ChengLaboratory of Feed Biotechnology, State Key Laboratory of Animal Nutrition, College of Animal Science and Technology, China Agricultural University, Beijing 100193, China.
Marhaba AhmatLaboratory of Feed Biotechnology, State Key Laboratory of Animal Nutrition, College of Animal Science and Technology, China Agricultural University, Beijing 100193, China.
Jun-Yong WangLaboratory of Feed Biotechnology, State Key Laboratory of Animal Nutrition, College of Animal Science and Technology, China Agricultural University, Beijing 100193, China.
Lu-Lu ZhangSchool of Pharmaceutical Sciences, Tsinghua University, Beijing 100084, China.
Xu-Biao WeiSchool of Pharmaceutical Sciences, Tsinghua University, Beijing 100084, China.
Xiu-Dong LiaoMineral Nutrition Research Division, State Key Laboratory of Animal Nutrition, Institute of Animal Sciences, Chinese Academy of Agricultural Sciences, Beijing 100193, China.
Ri-Jun ZhangLaboratory of Feed Biotechnology, State Key Laboratory of Animal Nutrition, College of Animal Science and Technology, China Agricultural University, Beijing 100193, China.
State Key Laboratory of Animal NutritionCenter for Life Sciences · CNChinese Academy of Agricultural Sciences · CNHebei Normal University of Science and Technology · CNSichuan University of Science and Engineering · CN

Funding

National Natural Science Foundation of China 31572442
6 · The paper itself

Abstract

The increasing numbers of infections caused by multidrug-resistant (MDR) pathogens highlight the urgent need for new alternatives to conventional antibiotics. Antimicrobial peptides have the potential to be promising alternatives to antibiotics because of their effective bactericidal activity and highly selective toxicity. The present study was conducted to investigate the antibacterial, antibiofilm, and anti-adhesion activities of different CTP peptides (CTP: the original hybrid peptide cathelicidin 2 (1-13)-thymopentin (TP5); CTP-NH

Indexed as

CathelicidinsThymopentinBiofilmsCell AdhesionMethicillin-Resistant Staphylococcus aureusMicrobial Sensitivity TestsCathelicidinsThymopentinanti-adhesionantibacterialantibiofilmantimicrobial peptidescathelicidin 2 (1-13)-thymopentin (TP5)multidrug resistanceStaphylococcus aureus

Identifiers

PMID34769113
PMCPMC8583881
OpenAlexW3208089356

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.