Evidence map›Paper›PMID 34769078›Full record

ArticleInternational journal of molecular sciences2021

Identification of Signaling Pathways for Early Embryonic Lethality and Developmental Retardation in

Jeyoung Bang, Minguk Han, Tack-Jin Yoo, Lu Qiao, Jisu Jung, Jiwoon Na, Bradley A Carlson, Vadim N Gladyshev, Dolph L Hatfield, Jin-Hong Kim and 2 more

Open access · goldAbstract read
In one paragraph

Article in International journal of molecular sciences, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
2.3field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 15 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Review
  5. SEPHS1: Its evolution, function and roles in development and diseases.Archives of biochemistry and biophysics · 2022
    Article
  6. Article
  7. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 4 institutions in 2 countries.

Jeyoung BangInterdisciplinary Program in Bioinformatics, College of Natural Sciences, Seoul National University, Seoul 08826, Korea.
Minguk HanInterdisciplinary Program in Bioinformatics, College of Natural Sciences, Seoul National University, Seoul 08826, Korea.
Tack-Jin YooSchool of Biological Sciences, College of Natural Sciences, Seoul National University, Seoul 08826, Korea.
Lu QiaoSchool of Biological Sciences, College of Natural Sciences, Seoul National University, Seoul 08826, Korea.
Jisu JungSchool of Biological Sciences, College of Natural Sciences, Seoul National University, Seoul 08826, Korea.
Jiwoon NaSchool of Biological Sciences, College of Natural Sciences, Seoul National University, Seoul 08826, Korea.
Bradley A CarlsonMouse Cancer Genetics Program, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA.
Vadim N GladyshevDepartment of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, USA.
Dolph L HatfieldMouse Cancer Genetics Program, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA.
Jin-Hong KimSchool of Biological Sciences, College of Natural Sciences, Seoul National University, Seoul 08826, Korea.ORCID 0000-0002-6480-1929
Lark Kyun KimSeverance Biomedical Science Institute, Graduate School of Medical Science, Brain Korea 21 Project, Gangnam Severance Hospital, Yonsei University College of Medicine, Seoul 06230, Korea.ORCID 0000-0001-5983-4470
Byeong Jae LeeInterdisciplinary Program in Bioinformatics, College of Natural Sciences, Seoul National University, Seoul 08826, Korea.
Seoul National University · KRNational Institutes of Health · USBrigham and Women's Hospital · USYonsei University · KR

Funding

National Research Foundation of Korea NRF-2016K1A3A1A20006069National Research Foundation of Korea NRF-2018R1D1A1A09083692
6 · The paper itself

Abstract

Selenophosphate synthetase 1 (SEPHS1) plays an essential role in cell growth and survival. However, the underlying molecular mechanisms remain unclear. In the present study, the pathways regulated by SEPHS1 during gastrulation were determined by bioinformatical analyses and experimental verification using systemic knockout mice targeting

Indexed as

GastrulationGene Expression Regulation, DevelopmentalAnimalsEmbryo LossFemaleGene DeletionMiceMice, Inbred C57BLMice, KnockoutPhosphotransferasesPregnancySignal TransductionPhosphotransferasesSephs1 protein, mouseearly embryogenesisembryonic lethalityreactive oxygen speciesseleniumselenoproteinSEPHS1

Identifiers

PMID34769078
PMCPMC8583877
OpenAlexW3210599409

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.