Evidence map›Paper›PMID 34769068›Full record

ArticleInternational journal of molecular sciences2021

Differential Effects of Human P301L Tau Expression in Young versus Aged Mice.

Holly C Hunsberger, Sharay E Setti, Carolyn C Rudy, Daniel S Weitzner, Jeremiah C Pfitzer, Kelli L McDonald, Hao Hong, Subhrajit Bhattacharya, Vishnu Suppiramaniam, Miranda N Reed

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of molecular sciences, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.7field-weighted citation impact, top 30% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 10 citations in OpenAlex.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 4 institutions in 2 countries.

Holly C HunsbergerDivision of Systems Neuroscience, Research Foundation for Mental Hygiene, Inc. (RFMH)/New York State Psychiatric Institute (NYSPI), New York, NY 10032, USA.ORCID 0000-0002-4797-9311
Sharay E SettiDrug Discovery and Development, School of Pharmacy, Auburn University, Auburn, AL 36849, USA.
Carolyn C RudyDepartment of Psychology, West Virginia University, Morgantown, WV 26506, USA.
Daniel S WeitznerDepartment of Psychology, West Virginia University, Morgantown, WV 26506, USA.
Jeremiah C PfitzerDrug Discovery and Development, School of Pharmacy, Auburn University, Auburn, AL 36849, USA.
Kelli L McDonaldDrug Discovery and Development, School of Pharmacy, Auburn University, Auburn, AL 36849, USA.
Hao HongDepartment of Pharmacology, Key Laboratory of Neuropsychiatric Diseases, China Pharmaceutical University, Nanjing 210009, China.
Subhrajit BhattacharyaDrug Discovery and Development, School of Pharmacy, Auburn University, Auburn, AL 36849, USA.
Vishnu SuppiramaniamDrug Discovery and Development, School of Pharmacy, Auburn University, Auburn, AL 36849, USA.
Miranda N ReedDrug Discovery and Development, School of Pharmacy, Auburn University, Auburn, AL 36849, USA.ORCID 0000-0002-8465-5594
Auburn University · USWest Virginia University · USChina Pharmaceutical University · CNColumbia University Irving Medical Center · US

Funding

NIH HHS NIH/NIA R15AG045812
6 · The paper itself

Abstract

The greatest risk factor for developing Alzheimer's disease (AD) is increasing age. Understanding the changes that occur in aging that make an aged brain more susceptible to developing AD could result in novel therapeutic targets. In order to better understand these changes, the current study utilized mice harboring a regulatable mutant P301L human

Indexed as

AgingGene ExpressionAlzheimer DiseaseAnimalsGlutamic AcidHumansMaleMaze LearningMiceMice, TransgenicMutationtau ProteinsGlutamic AcidMAPT protein, humantau ProteinsagingAlzheimer’s diseaseglutamateP301L tau

Identifiers

PMID34769068
PMCPMC8583766
OpenAlexW3208906927

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.