Evidence map›Paper›PMID 34769052›Full record

ArticleInternational journal of molecular sciences2021

Infection of Brain Pericytes Underlying Neuropathology of COVID-19 Patients.

Matteo Bocci, Clara Oudenaarden, Xavier Sàenz-Sardà, Joel Simrén, Arvid Edén, Jonas Sjölund, Christina Möller, Magnus Gisslén, Henrik Zetterberg, Elisabet Englund and 1 more

Registry-linked trialOpen access · goldAbstract read
In one paragraph

Article in International journal of molecular sciences, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05669261 (A PILOT STUDY ON RESEARCH TREATMENT OF LONG COVID POST-ACUTE SEQUELAE OF SARS CoV-2 INFECTION), which is not on this map. Cited by 54 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
54citing papers in PubMed, 2 pooled it
6.5field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT05669261 phase1unknown statusnot on this mapstarted 2023, after this paper: background citation

A PILOT STUDY ON RESEARCH TREATMENT OF LONG COVID POST-ACUTE SEQUELAE OF SARS CoV-2 INFECTION ("PASC") USING ATCell™

TypeinterventionalSponsorAmerican CryoStem CorporationRan2023 to 2024Enrolled20ConditionsLong COVIDArmsAdipose Tissue Harvest, ATCell
3 · Its place in the literature

Who cites it

54 citing papers in PubMed, 2 syntheses or guidelines pooled it, 64 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Human brain matters: Navigating the neuropathology of COVID-19.Brain pathology (Zurich, Switzerland) · 2026
    Review
  4. Article
  5. Article
  6. Article
  7. Article
  8. Review
  9. Article
  10. Article
  11. Article
  12. Article
  13. Review
  14. Article
  15. Article
  16. Review
  17. Observational
  18. Review
  19. DoFrontiers in nutrition · 2024
    Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 3 institutions in 2 countries.

Matteo BocciDepartment of Laboratory Medicine, Division of Translational Cancer Research, Lund University Cancer Centre, Medicon Village, Lund University, 223 81 Lund, Sweden.ORCID 0000-0002-8774-0006
Clara OudenaardenDepartment of Laboratory Medicine, Division of Translational Cancer Research, Lund University Cancer Centre, Medicon Village, Lund University, 223 81 Lund, Sweden.ORCID 0000-0002-5466-0755
Xavier Sàenz-SardàDepartment of Clinical Sciences Lund, Division of Pathology, Lund University, 221 84 Lund, Sweden.
Joel SimrénDepartment of Psychiatry and Neurochemistry, Institute of Neuroscience & Physiology, The Sahlgrenska Academy at the University of Gothenburg, 431 41 Gothenburg, Sweden.ORCID 0000-0001-5081-6604
Arvid EdénDepartment of Infectious Diseases, Institute of Biomedicine, The Sahlgrenska Academy at the University of Gothenburg, 413 46 Gothenburg, Sweden.
Jonas SjölundDepartment of Laboratory Medicine, Division of Translational Cancer Research, Lund University Cancer Centre, Medicon Village, Lund University, 223 81 Lund, Sweden.ORCID 0000-0002-6992-3415
Christina MöllerDepartment of Laboratory Medicine, Division of Translational Cancer Research, Lund University Cancer Centre, Medicon Village, Lund University, 223 81 Lund, Sweden.
Magnus GisslénDepartment of Infectious Diseases, Institute of Biomedicine, The Sahlgrenska Academy at the University of Gothenburg, 413 46 Gothenburg, Sweden.
Henrik ZetterbergDepartment of Psychiatry and Neurochemistry, Institute of Neuroscience & Physiology, The Sahlgrenska Academy at the University of Gothenburg, 431 41 Gothenburg, Sweden.
Elisabet EnglundDepartment of Clinical Sciences Lund, Division of Pathology, Lund University, 221 84 Lund, Sweden.ORCID 0000-0002-2708-2443
Kristian PietrasDepartment of Laboratory Medicine, Division of Translational Cancer Research, Lund University Cancer Centre, Medicon Village, Lund University, 223 81 Lund, Sweden.ORCID 0000-0001-6738-4705
Lund University · SESahlgrenska University Hospital · SEUniversity of Gothenburg · SE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

A wide range of neurological manifestations have been associated with the development of COVID-19 following SARS-CoV-2 infection. However, the etiology of the neurological symptomatology is still largely unexplored. Here, we used state-of-the-art multiplexed immunostaining of human brains (

Indexed as

Angiotensin-Converting Enzyme 2AnimalsBlood-Brain BarrierBrainCase-Control StudiesCOVID-19Encephalitis, ViralFibrinogenHumansImmunohistochemistryMicePericytesReceptor, Platelet-Derived Growth Factor betaACE2 protein, humanAce2 protein, mouseAngiotensin-Converting Enzyme 2FibrinogenReceptor, Platelet-Derived Growth Factor betaACE2blood–brain barrierbrainCOVID-19infectionmultiplexed IHCpericytesSARS-CoV-2vasculature

Identifiers

PMID34769052
PMCPMC8583965
OpenAlexW3210744720

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.