ArticleInternational journal of molecular sciences2021
The Intervention and Mechanism of Action for Aloin against Subchronic Aflatoxin B1 Induced Hepatic Injury in Rats.
Article in International journal of molecular sciences, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
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4 citing papers in PubMed, 9 citations in OpenAlex.
- Compound Abrus cantoniensis Extract Alleviates AFBAdvanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- A mugwort-based Chinese herbal mixture of five herbs improved oviduct health in laying hens under LPS challenge.Poultry science · 2026Article
- Intervention mechanism of marine-based chito-oligosaccharide on acute liver injury induced by AFBBioresources and bioprocessing · 2024Article
- Arabic Gum Could Alleviate the Aflatoxin BToxins · 2022Article
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Authors and funding
8 authors at 1 institution in 1 country.
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Abstract
As a class of difurancoumarin compounds with similar structures, aflatoxins (AF) are commonly found in the environment, soil, and food crops. AF pose a serious threat to the health of humans, poultry, and livestock. This study aimed to investigate the neuroprotective effect and detailed mechanism of aloin on hepatic injury induced by subchronic AFB1 in rats. The result showed that aloin could significantly inhibit the decrease in food intake, body weight growth, immune organ index, and serum albumin content caused by long-term AFB1 exposure. Meanwhile, aloin reduced the level of serum liver function and improved renal swelling and pathological changes of liver tissue. Aloin could also inhibit liver lipid peroxidation and improve liver antioxidant capacity. Further investigation revealed that aloin inhibited the activity and expression of hepatic CYP1A2 and CYP3A4 and down-regulated
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