Evidence map›Paper›PMID 34769023›Full record

ArticleInternational journal of molecular sciences2021

The Bacterial Amyloids Phenol Soluble Modulins from

Caroline Haikal, Lei Ortigosa-Pascual, Zahra Najarzadeh, Katja Bernfur, Alexander Svanbergsson, Daniel E Otzen, Sara Linse, Jia-Yi Li

Open access · goldAbstract read
In one paragraph

Article in International journal of molecular sciences, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
1.7field-weighted citation impact, top 16% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 19 citations in OpenAlex.

  1. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 3 countries.

Caroline HaikalNeural Plasticity and Repair Unit, Wallenberg Neuroscience Center, Department of Experimental Medical Science, Lund University, 22184 Lund, Sweden.ORCID 0000-0002-9066-5940
Lei Ortigosa-PascualDepartment of Biochemistry and Structural Biology, Lund University, 22100 Lund, Sweden.
Zahra NajarzadehInterdisciplinary Nanoscience Centre (iNANO), Aarhus University, Gustav Wieds Vej 14, 8000 Aarhus C, Denmark.ORCID 0000-0002-0044-7537
Katja BernfurDepartment of Biochemistry and Structural Biology, Lund University, 22100 Lund, Sweden.
Alexander SvanbergssonNeural Plasticity and Repair Unit, Wallenberg Neuroscience Center, Department of Experimental Medical Science, Lund University, 22184 Lund, Sweden.ORCID 0000-0003-4435-7653
Daniel E OtzenInterdisciplinary Nanoscience Centre (iNANO), Aarhus University, Gustav Wieds Vej 14, 8000 Aarhus C, Denmark.ORCID 0000-0002-2918-8989
Sara LinseDepartment of Biochemistry and Structural Biology, Lund University, 22100 Lund, Sweden.
Jia-Yi LiNeural Plasticity and Repair Unit, Wallenberg Neuroscience Center, Department of Experimental Medical Science, Lund University, 22184 Lund, Sweden.ORCID 0000-0002-7770-7376
Lund University · SEAarhus University · DK

Funding

EU-Horizon 2020 MSCA-ITN-2016, SynDeGenEU-JPND aSynProtec and REfrAMEKey Field Research Development Program of Guangdong Province 2018B030337001Multipark Jia-Yi LiNational Natural Science Foundation of China 81430025, 31800898, and U1801681Parkinsonfonden Jia-Yi LiSwedish Research Council K2015-61X-22297-03-4; 2019-01551; 2015-00143
6 · The paper itself

Abstract

Aggregated α-synuclein (α-syn) is the main constituent of Lewy bodies, which are a pathological hallmark of Parkinson's disease (PD). Environmental factors are thought to be potential triggers capable of initiating the aggregation of the otherwise monomeric α-syn. Braak's seminal work redirected attention to the intestine and recent reports of dysbiosis have highlighted the potential causative role of the microbiome in the initiation of pathology of PD.

Indexed as

alpha-SynucleinAmyloidCell LineHEK293 CellsHumansParkinson DiseasePhenolsPhosphorylationProtein Aggregation, PathologicalStaphylococcus aureusalpha-SynucleinAmyloidPhenolsaggregationalpha-synucleinbacterial amyloidsParkinson’s diseaseprotein folding

Identifiers

PMID34769023
PMCPMC8584152
OpenAlexW3211178728

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.