Evidence map›Paper›PMID 34768995›Full record

ArticleInternational journal of molecular sciences2021

Deciphering the Genomic Landscape and Pharmacological Profile of Uncommon Entities of Adult Rhabdomyosarcomas.

Alessandro De Vita, Silvia Vanni, Valentina Fausti, Claudia Cocchi, Federica Recine, Giacomo Miserocchi, Chiara Liverani, Chiara Spadazzi, Massimo Bassi, Manlio Gessaroli and 16 more

Open access · goldAbstract read
In one paragraph

Article in International journal of molecular sciences, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.

0numbers the graph read from it
0cells of the map it votes in
30citing papers in PubMed
3.4field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

30 citing papers in PubMed, 30 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

26 authors at 5 institutions in 1 country.

Alessandro De VitaOsteoncology and Rare Tumors Center, IRCCS Istituto Romagnolo per lo Studio dei Tumori (IRST) "Dino Amadori", 47014 Meldola, Italy.ORCID 0000-0002-1677-5797
Silvia VanniOsteoncology and Rare Tumors Center, IRCCS Istituto Romagnolo per lo Studio dei Tumori (IRST) "Dino Amadori", 47014 Meldola, Italy.
Valentina FaustiOsteoncology and Rare Tumors Center, IRCCS Istituto Romagnolo per lo Studio dei Tumori (IRST) "Dino Amadori", 47014 Meldola, Italy.
Claudia CocchiOsteoncology and Rare Tumors Center, IRCCS Istituto Romagnolo per lo Studio dei Tumori (IRST) "Dino Amadori", 47014 Meldola, Italy.ORCID 0000-0002-7736-9039
Federica RecineOsteoncology and Rare Tumors Center, IRCCS Istituto Romagnolo per lo Studio dei Tumori (IRST) "Dino Amadori", 47014 Meldola, Italy.
Giacomo MiserocchiOsteoncology and Rare Tumors Center, IRCCS Istituto Romagnolo per lo Studio dei Tumori (IRST) "Dino Amadori", 47014 Meldola, Italy.
Chiara LiveraniOsteoncology and Rare Tumors Center, IRCCS Istituto Romagnolo per lo Studio dei Tumori (IRST) "Dino Amadori", 47014 Meldola, Italy.
Chiara SpadazziOsteoncology and Rare Tumors Center, IRCCS Istituto Romagnolo per lo Studio dei Tumori (IRST) "Dino Amadori", 47014 Meldola, Italy.
Massimo BassiOral and Maxillofacial Surgery Unit, "Maurizio Bufalini" Hospital, 47521 Cesena, Italy.
Manlio GessaroliOral and Maxillofacial Surgery Unit, "Maurizio Bufalini" Hospital, 47521 Cesena, Italy.
Angelo CampobassiOral and Maxillofacial Surgery Unit, "Maurizio Bufalini" Hospital, 47521 Cesena, Italy.
Giovanni De LucaPathology Unit, "Maurizio Bufalini" Hospital, 47521 Cesena, Italy.
Federica PieriPathology Unit, "Morgagni-Pierantoni" Hospital, 47121 Forlì, Italy.
Anna FarnediPathology Unit, "Morgagni-Pierantoni" Hospital, 47121 Forlì, Italy.
Eugenia FranchiniBiosciences Laboratory, IRCCS Istituto Romagnolo per lo Studio dei Tumori (IRST) "Dino Amadori", 47014 Meldola, Italy.
Anna FerrariBiosciences Laboratory, IRCCS Istituto Romagnolo per lo Studio dei Tumori (IRST) "Dino Amadori", 47014 Meldola, Italy.ORCID 0000-0002-7022-9906
Chiara DomizioBiosciences Laboratory, IRCCS Istituto Romagnolo per lo Studio dei Tumori (IRST) "Dino Amadori", 47014 Meldola, Italy.
Enrico CavagnaDepartment of Diagnostic Imaging, Azienda Unità Sanitaria Locale della Romagna (AUSL Romagna), 47923 Rimini, Italy.
Lorena GurrieriOsteoncology and Rare Tumors Center, IRCCS Istituto Romagnolo per lo Studio dei Tumori (IRST) "Dino Amadori", 47014 Meldola, Italy.
Alberto BongiovanniOsteoncology and Rare Tumors Center, IRCCS Istituto Romagnolo per lo Studio dei Tumori (IRST) "Dino Amadori", 47014 Meldola, Italy.ORCID 0000-0002-3845-4687
Nada RivaOsteoncology and Rare Tumors Center, IRCCS Istituto Romagnolo per lo Studio dei Tumori (IRST) "Dino Amadori", 47014 Meldola, Italy.
Sebastiano CalponaOsteoncology and Rare Tumors Center, IRCCS Istituto Romagnolo per lo Studio dei Tumori (IRST) "Dino Amadori", 47014 Meldola, Italy.ORCID 0000-0003-3154-8346
Giandomenico Di MennaOsteoncology and Rare Tumors Center, IRCCS Istituto Romagnolo per lo Studio dei Tumori (IRST) "Dino Amadori", 47014 Meldola, Italy.
Silvia Angela DebonisOsteoncology and Rare Tumors Center, IRCCS Istituto Romagnolo per lo Studio dei Tumori (IRST) "Dino Amadori", 47014 Meldola, Italy.
Toni IbrahimOsteoncology and Rare Tumors Center, IRCCS Istituto Romagnolo per lo Studio dei Tumori (IRST) "Dino Amadori", 47014 Meldola, Italy.ORCID 0000-0003-0259-4167
Laura MercataliOsteoncology and Rare Tumors Center, IRCCS Istituto Romagnolo per lo Studio dei Tumori (IRST) "Dino Amadori", 47014 Meldola, Italy.
Istituto Scientifico Romagnolo per lo Studio e la Cura dei Tumori · ITOspedale “M. Bufalini” di Cesena · ITOspedale G.B. Morgagni - L.Pierantoni · ITAzienda Ospedaliera San Giovanni Addolorata · ITAzienda Unità Sanitaria Locale Della Romagna · IT

Funding

Alleanza Contro il Cancro N/AMinistero della Salute N/A
6 · The paper itself

Abstract

Adult rhabdomyosarcoma (RMS) represents an uncommon entity with an incidence of less than 3% of all soft tissue sarcomas (STS). Consequently, the natural history and the clinical management of this disease are infrequently reported. In order to fill this gap, we investigated the molecular biology of an adult RMS case series. The expression of epithelial mesenchymal transition-related gene and chemoresistance-related gene panels were evaluated. Moreover, taking advantage of our STS translational model combining patient-derived primary culture and 3D-scaffold, the pharmacological profile of an adult head and neck sclerosing RMS was assessed. Furthermore, NGS, microsatellite instability, and in silico analyses were carried out. RT-PCR identified the upregulation of

Indexed as

AdultAgedBiomarkers, TumorEpithelial-Mesenchymal TransitionFemaleGenomicsHumansMaleMicrosatellite InstabilityMutationRhabdomyosarcomaSarcomaSoft Tissue NeoplasmsUp-RegulationBiomarkers, Tumor3D collagen-based scaffold culture systemsadult rhabdomyosarcomachemotherapygene expression profilingprimary culture

Identifiers

PMID34768995
PMCPMC8584142
OpenAlexW3208439300

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.