Evidence map›Paper›PMID 34768985›Full record

ArticleInternational journal of molecular sciences2021

Not All Lectins Are Equally Suitable for Labeling Rodent Vasculature.

Roberta Battistella, Marios Kritsilis, Hana Matuskova, Douglas Haswell, Anne Xiaoan Cheng, Anja Meissner, Maiken Nedergaard, Iben Lundgaard

Open access · goldAbstract read
In one paragraph

Article in International journal of molecular sciences, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.

0numbers the graph read from it
0cells of the map it votes in
19citing papers in PubMed
1.8field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

19 citing papers in PubMed, 27 citations in OpenAlex.

  1. CD4Science (New York, N.Y.) · 2026
    Article
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  3. Review
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  14. Article
  15. Plasma Galectin-4 Levels Are Increased after Stroke in Mice and Humans.International journal of molecular sciences · 2023
    Article
  16. Article
  17. Article
  18. High-resolution 3D demonstration of regional heterogeneity in the glymphatic system.Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2022
    Article
  19. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 4 countries.

Roberta BattistellaDepartment of Experimental Medical Science, Faculty of Medicine, Lund University, 22362 Lund, Sweden.ORCID 0000-0002-7072-7286
Marios KritsilisDepartment of Experimental Medical Science, Faculty of Medicine, Lund University, 22362 Lund, Sweden.ORCID 0000-0003-1610-7040
Hana MatuskovaDepartment of Experimental Medical Science, Faculty of Medicine, Lund University, 22362 Lund, Sweden.
Douglas HaswellCenter for Translational Neuromedicine, Department of Neurosurgery, University of Rochester Medical Center, Rochester, NY 14642, USA.
Anne Xiaoan ChengCenter for Translational Neuromedicine, Department of Neurosurgery, University of Rochester Medical Center, Rochester, NY 14642, USA.
Anja MeissnerDepartment of Experimental Medical Science, Faculty of Medicine, Lund University, 22362 Lund, Sweden.ORCID 0000-0002-0793-7213
Maiken NedergaardCenter for Translational Neuromedicine, Department of Neurosurgery, University of Rochester Medical Center, Rochester, NY 14642, USA.
Iben LundgaardDepartment of Experimental Medical Science, Faculty of Medicine, Lund University, 22362 Lund, Sweden.
Lund University · SEUniversity of Rochester Medical Center · USUniversity of Copenhagen · DK

Funding

Para-Vascular Basis of Small Vessel DiseaseR01NS100366 · NINDS · UNIVERSITY OF ROCHESTER · PI NEDERGAARD, MAIKEN · 2016 to 2020
$3.8M
Age and AD related bottlenecks in glymphatic-lymphatic waste transportRF1AG057575 · NIA · UNIVERSITY OF ROCHESTER · PI NEDERGAARD, MAIKEN · 2017 to 2017
$3.2M
The glymphatic system at the crossroad of integrative health approaches inchronic painR01AT011439 · NCCIH · UNIVERSITY OF ROCHESTER · PI NEDERGAARD, MAIKEN · 2021 to 2025
$3.1M
Capillary hyperemia in white matter: Novel mechanistic insight and effect of hypertension and agingRF1NS110049 · NINDS · UNIVERSITY OF ROCHESTER · PI NEDERGAARD, MAIKEN, WAN, JIANDI · 2018 to 2018
$2.9M
Åhlén-stiftelsen 193082Åhlén-stiftelsen 203102Knut och Alice Wallenbergs Stiftelse F2015/2112NCCIH NIH HHS R01 AT011439NIA NIH HHS RF1 AG057575NINDS NIH HHS R01 NS100366NINDS NIH HHS RF1 NS110049
6 · The paper itself

Abstract

The vascular system is vital for all tissues and the interest in its visualization spans many fields. A number of different plant-derived lectins are used for detection of vasculature; however, studies performing direct comparison of the labeling efficacy of different lectins and techniques are lacking. In this study, we compared the labeling efficacy of three lectins:

Indexed as

AnimalsBlood VesselsBrainCardiovascular SystemLectinsMaleMiceMice, Inbred C57BLPlant LectinsRodentiaStaining and LabelingWheat Germ AgglutininsGriffonia simplicifolia lectinsLectinsPlant Lectinstomato lectinWheat Germ Agglutininsangiogenesisblood vesselslectin angiographylectinsstrokevascular research

Identifiers

PMID34768985
PMCPMC8584019
OpenAlexW3209210295

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.