Evidence map›Paper›PMID 34768967›Full record

ReviewInternational journal of molecular sciences2021

DUSP9, a Dual-Specificity Phosphatase with a Key Role in Cell Biology and Human Diseases.

Fatma Zohra Khoubai, Christophe F Grosset

Open access · goldAbstract readReview
In one paragraph

Review in International journal of molecular sciences, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.

0numbers the graph read from it
0cells of the map it votes in
26citing papers in PubMed
1.5field-weighted citation impact, top 17% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

26 citing papers in PubMed, 36 citations in OpenAlex.

  1. Applied and environmental microbiology · 2026
    Article
  2. Article
  3. Review
  4. Article
  5. MAP kinase phosphatases in metabolic diseases.Trends in endocrinology and metabolism: TEM · 2026
    Review
  6. Article
  7. Review
  8. Review
  9. Article
  10. Review
  11. Article
  12. Article
  13. Article
  14. Article
  15. Article
  16. Article
  17. Article
  18. The signaling pathways in obesity-related complications.Journal of cell communication and signaling · 2024
    Review
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

Fatma Zohra KhoubaiINSERM, MIRCADE Team, UMR1035 Biothérapie des Maladies Génétiques, Désordres Inflammatoires et Cancer, BMGIC, Université de Bordeaux, 146 Rue Léo Saignat, F-33000 Bordeaux, France.ORCID 0000-0001-9988-2856
Christophe F GrossetINSERM, MIRCADE Team, UMR1035 Biothérapie des Maladies Génétiques, Désordres Inflammatoires et Cancer, BMGIC, Université de Bordeaux, 146 Rue Léo Saignat, F-33000 Bordeaux, France.ORCID 0000-0002-0479-6291
Université de Bordeaux · FR

Funding

Charities Aidons Marina, E.S.CA.P.E., Eva pour la Vie, Les Récoltes de l'Espoir, Sphères N/AFondation Groupama pour la Santé N/AGroupama Centre-Atlantique N/ALa Fondation ARC pour la Recherche sur le Cancer contract N° PJA 20191209631The Ligue Nationale contre le Cancer contract n°AAPPEAC2018.LCC/CGthe Région Nouvelle-Aquitaine N°2018-1R30114
6 · The paper itself

Abstract

Mitogen-activated protein kinases (MAPKs) are essential for proper cell functioning as they regulate many molecular effectors. Careful regulation of MAPKs is therefore required to avoid MAPK pathway dysfunctions and pathologies. The mammalian genome encodes about 200 phosphatases, many of which dephosphorylate the MAPKs and bring them back to an inactive state. In this review, we focus on the normal and pathological functions of dual-specificity phosphatase 9 (

Indexed as

AnimalsDual-Specificity PhosphatasesFemaleGene Expression Regulation, EnzymologicHeart DiseasesHumansMaleMAP Kinase Signaling SystemMetabolic DiseasesMetabolic Networks and PathwaysMiceMitogen-Activated Protein Kinase PhosphatasesModels, MolecularMouse Embryonic Stem CellsNeoplasmsProtein ConformationDual-Specificity PhosphatasesDUSP9 protein, humanDusp9 protein, mouseMitogen-Activated Protein Kinase Phosphatasescancerdual-specificity phosphataseMAP kinase phosphatasemetabolic syndromesmitogen-activated protein kinasesex differencestherapy

Identifiers

PMID34768967
PMCPMC8583968
OpenAlexW3209180084

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.