Evidence map›Paper›PMID 34768964›Full record

ReviewInternational journal of molecular sciences2021

The Bioactivity of Thiazolidin-4-Ones: A Short Review of the Most Recent Studies.

Dominika Mech, Antonina Kurowska, Nazar Trotsko

Abstract readReview
In one paragraph

Review in International journal of molecular sciences, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed.

  1. Article
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  4. Article
  5. Article
  6. Review
  7. Article
  8. Review
  9. Thiazolidine-4-one Analogues: Synthesis,Central nervous system agents in medicinal chemistry · 2025
    Article
  10. Article
  11. Article
  12. Article
  13. Article
  14. Review
  15. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Dominika MechDepartment of Organic Chemistry, Faculty of Pharmacy, Medical University of Lublin, 20-093 Lublin, Poland.ORCID 0000-0002-8690-9965
Antonina KurowskaDepartment of Organic Chemistry, Faculty of Pharmacy, Medical University of Lublin, 20-093 Lublin, Poland.ORCID 0000-0002-7844-8767
Nazar TrotskoDepartment of Organic Chemistry, Faculty of Pharmacy, Medical University of Lublin, 20-093 Lublin, Poland.ORCID 0000-0002-8817-7470

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Thiazolidin-4-ones is an important heterocyclic ring system of a pharmacophore and a privileged scaffold in medicinal chemistry. This review is focused on the latest scientific reports regarding biological activities of thiazolidin-4-ones published in 2020 and 2021. The review covers recent information about antioxidant, anticancer, anti-inflammatory, analgesic, anticonvulsant, antidiabetic, antiparasitic, antimicrobial, antitubercular and antiviral properties of thiazolidin-4-ones. Additionally, the influence of different substituents in molecules on their biological activity was discussed in this paper. Thus, this study may help to optimize the structure of thiazolidin-4-one derivatives as more efficient drug agents. Presented information may be used as a practical hint for rational design of new small molecules with biological activity, especially among thiazolidin-4-ones.

Indexed as

AnalgesicsAnimalsAnticonvulsantsAnti-Infective AgentsAnti-Inflammatory AgentsAntineoplastic AgentsAntioxidantsHumansHypoglycemic AgentsMolecular StructureNeuroprotective AgentsStructure-Activity RelationshipThiazolidinesAnalgesicsAnticonvulsantsAnti-Infective AgentsAnti-Inflammatory AgentsAntineoplastic AgentsAntioxidantsHypoglycemic AgentsNeuroprotective AgentsThiazolidinesanticancer activityantidiabetic activityanti-inflammatory activityantimicrobial activityantioxidant activityantiparasitic activityantitubercular activitymultitarget activitystructure-activity relationshipthiazolidine-4-ones

Identifiers

PMID34768964
PMCPMC8584074

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.