Evidence map›Paper›PMID 34768935›Full record

ArticleInternational journal of molecular sciences2021

OCT1 Is a Poor Prognostic Factor for Breast Cancer Patients and Promotes Cell Proliferation via Inducing NCAPH.

Takuya Ogura, Kotaro Azuma, Junichiro Sato, Keiichi Kinowaki, Ken-Ichi Takayama, Toshihiko Takeiwa, Hidetaka Kawabata, Satoshi Inoue

Open access · goldAbstract read
In one paragraph

Article in International journal of molecular sciences, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed
2.9field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed, 40 citations in OpenAlex.

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  13. FGFR2 genetic variants in women with breast cancer.Molecular medicine reports · 2023
    Article
  14. Article
  15. Protooncogenic Role ofBioMed research international · 2023
    Article
  16. Article
  17. Molecular Research and Treatment of Breast Cancer.International journal of molecular sciences · 2022
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 1 country.

Takuya OguraDepartment of Systems Aging Science and Medicine, Tokyo Metropolitan Institute of Gerontology, 35-2 Sakae-cho, Itabashi-ku, Tokyo 173-0015, Japan.ORCID 0000-0002-0972-9952
Kotaro AzumaDepartment of Systems Aging Science and Medicine, Tokyo Metropolitan Institute of Gerontology, 35-2 Sakae-cho, Itabashi-ku, Tokyo 173-0015, Japan.
Junichiro SatoDepartment of Pathology, Toranomon Hospital, 2-2-2 Toranomon, Minato-ku, Tokyo 105-8470, Japan.
Keiichi KinowakiDepartment of Pathology, Toranomon Hospital, 2-2-2 Toranomon, Minato-ku, Tokyo 105-8470, Japan.ORCID 0000-0001-7915-9177
Ken-Ichi TakayamaDepartment of Systems Aging Science and Medicine, Tokyo Metropolitan Institute of Gerontology, 35-2 Sakae-cho, Itabashi-ku, Tokyo 173-0015, Japan.ORCID 0000-0002-2832-1434
Toshihiko TakeiwaDepartment of Systems Aging Science and Medicine, Tokyo Metropolitan Institute of Gerontology, 35-2 Sakae-cho, Itabashi-ku, Tokyo 173-0015, Japan.
Hidetaka KawabataDepartment of Breast and Endocrine Surgery, Toranomon Hospital, 2-2-2 Toranomon, Minato-ku, Tokyo 105-8470, Japan.
Satoshi InoueDepartment of Systems Aging Science and Medicine, Tokyo Metropolitan Institute of Gerontology, 35-2 Sakae-cho, Itabashi-ku, Tokyo 173-0015, Japan.ORCID 0000-0003-1247-3844
Tokyo Metropolitan Institute of Gerontology · JPToranomon Hospital · JPTokyo Medical and Dental University · JP

Funding

Japan Society for the Promotion of Science 17K10571Japan Society for the Promotion of Science 20K08954Japan Society for the Promotion of Science 20K21667Japan Society for the Promotion of Science 21H04829Kao Health Science Foundation KHSFMinistry of Education, Culture, Sports, Science and Technology P-CREATEOkinaka Memorial Institute for Medical Research OMIMRUehara Memorial Foundation UMFYamaguchi Endocrine Research Foundation YERF
6 · The paper itself

Abstract

Octamer transcription factor 1 (OCT1) is a transcriptional factor reported to be a poor prognostic factor in various cancers. However, the clinical value of OCT1 in breast cancer is not fully understood. In the present study, an immunohistochemical study of OCT1 protein was performed using estrogen receptor (ER)-positive breast cancer tissues from 108 patients. Positive OCT1 immunoreactivity (IR) was associated with the shorter disease-free survival (DFS) of patients (

Indexed as

Biomarkers, TumorBreast NeoplasmsCell Cycle ProteinsCell Line, TumorCell ProliferationFemaleHEK293 CellsHumansMCF-7 CellsMiddle AgedNeoplasm InvasivenessNuclear ProteinsOctamer Transcription Factor-1PrognosisReceptors, EstrogenRNA InterferenceBiomarkers, TumorCell Cycle ProteinsNCAPH protein, humanNuclear ProteinsOctamer Transcription Factor-1POU2F1 protein, humanReceptors, EstrogenRNA, Small Interferingbreast cancercell cyclenon-structural maintenance of chromosomes condensin I complex subunit H (NCAPH)octamer transcription factor 1 (OCT1)proliferation

Identifiers

PMID34768935
PMCPMC8584020
OpenAlexW3210292913

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.