Evidence map›Paper›PMID 34768876›Full record

ArticleInternational journal of molecular sciences2021

Chlorogenic Acid Decreases Glutamate Release from Rat Cortical Nerve Terminals by P/Q-Type Ca

Yi-Chieh Hung, Yi-Hsiu Kuo, Pei-Wen Hsieh, Ting-Yang Hsieh, Jinn-Rung Kuo, Su-Jane Wang

Open access · goldAbstract read
In one paragraph

Article in International journal of molecular sciences, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
1.7field-weighted citation impact, top 17% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 21 citations in OpenAlex.

  1. Review
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  11. The GenusFrontiers in pharmacology · 2022
    Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 3 institutions in 1 country.

Yi-Chieh HungChi Mei Medical Center, Department of Neurosurgery, Tainan 71004, Taiwan.
Yi-Hsiu KuoGraduate Institute of Biomedical and Pharmaceutical Science, Fu Jen Catholic University, New Taipei City 24205, Taiwan.
Pei-Wen HsiehResearch Center for Chinese Herbal Medicine, College of Human Ecology, Chang Gung University of Science and Technology, Taoyuan 33303, Taiwan.ORCID 0000-0002-8882-4711
Ting-Yang HsiehProgram in Nutrition & Food Science, Fu Jen Catholic University, New Taipei City 24205, Taiwan.ORCID 0000-0003-2293-0404
Jinn-Rung KuoChi Mei Medical Center, Department of Neurosurgery, Tainan 71004, Taiwan.
Su-Jane WangResearch Center for Chinese Herbal Medicine, College of Human Ecology, Chang Gung University of Science and Technology, Taoyuan 33303, Taiwan.ORCID 0000-0002-4675-0259
Fu Jen Catholic University · TWChi Mei Medical Center · TWChang Gung University of Science and Technology · TW

Funding

Chi-Mei Medical Center 108-CM-FJU-02Ministry of Science and Technology MOST 110-2320-B-030-009
6 · The paper itself

Abstract

The glutamatergic neurotransmitter system has received substantial attention in research on the pathophysiology and treatment of neurological disorders. The study investigated the effect of the polyphenolic compound chlorogenic acid (CGA) on glutamate release in rat cerebrocortical nerve terminals (synaptosomes). CGA inhibited 4-aminopyridine (4-AP)-induced glutamate release from synaptosomes. This inhibition was prevented in the absence of extracellular Ca

Indexed as

AnimalsCalciumCalcium-Calmodulin-Dependent Protein Kinase Type 2Calcium ChannelsCalcium Channels, P-TypeCalcium Channels, Q-TypeCalmodulinCerebral CortexChlorogenic AcidExcitatory Amino Acid AgentsGlutamic AcidKainic AcidMaleMembrane PotentialsMolecular Docking SimulationNeuronsCalciumCalcium-Calmodulin-Dependent Protein Kinase Type 2Calcium ChannelsCalcium Channels, P-TypeCalcium Channels, Q-TypeCalmodulinChlorogenic AcidExcitatory Amino Acid AgentsGlutamic AcidKainic AcidNeuroprotective AgentsCaMKIIcerebral cortexchlorogenic acidglutamate releasekainic acidneuroprotectionP/Q-type Ca2+ channelsynaptosome

Identifiers

PMID34768876
PMCPMC8583876
OpenAlexW3208660866

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.