Evidence map›Paper›PMID 34768851›Full record

ArticleInternational journal of molecular sciences2021

The Potential Role of Electronegative High-Density Lipoprotein H5 Subfraction in RA-Related Atherosclerosis.

Ching-Kun Chang, Wei-Chung Cheng, Wen-Lung Ma, Po-Ku Chen, Chu-Huang Chen, Pei-Chun Shen, Chia-Ching Chen, Shih-Hsin Chang, Yi-Hua Lai, Der-Yuan Chen

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of molecular sciences, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.4field-weighted citation impact, top 42% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 6 citations in OpenAlex.

  1. Trial
  2. Dysfunctional high-density lipoprotein: an updated review.Frontiers in cardiovascular medicine · 2025
    Review
  3. Review
  4. Atherogenic circulating lipoproteins in ischemic stroke.Frontiers in cardiovascular medicine · 2024
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 4 institutions in 2 countries.

Ching-Kun ChangRheumatology and Immunology Center, China Medical University Hospital, Taichung 404, Taiwan.ORCID 0000-0001-7818-0847
Wei-Chung ChengThe Ph.D. Program for Cancer Biology and Drug Discovery, China Medical University and Academia Sinica, Taichung 404, Taiwan.ORCID 0000-0002-1229-4857
Wen-Lung MaGraduate Institute of Biomedical Sciences, China Medical University, Taichung 404, Taiwan.ORCID 0000-0002-5571-3302
Po-Ku ChenRheumatology and Immunology Center, China Medical University Hospital, Taichung 404, Taiwan.
Chu-Huang ChenVascular and Medicinal Research, Texas Heart Institute, Houston, TX 6770, USA.
Pei-Chun ShenResearch Center for Cancer Biology, China Medical University, Taichung 404, Taiwan.
Chia-Ching ChenSchool of Medicine, Chang Gung University, Tao-Yuan 333, Taiwan.
Shih-Hsin ChangRheumatology and Immunology Center, China Medical University Hospital, Taichung 404, Taiwan.
Yi-Hua LaiRheumatology and Immunology Center, China Medical University Hospital, Taichung 404, Taiwan.
Der-Yuan ChenRheumatology and Immunology Center, China Medical University Hospital, Taichung 404, Taiwan.ORCID 0000-0003-1266-1423
China Medical University · TWShinshu University · JPAsia University · TWNational Chung Hsing University · TW

Funding

China Medical University Hospital DMR-110-196Ministry of Science and Technology, Taiwan MOST 110-2314-B-039-051
6 · The paper itself

Abstract

Although the heterogeneity of high-density lipoprotein-cholesterol (HDL-c) composition is associated with atherosclerotic cardiovascular risk, the link between electronegative subfractions of HDL-c and atherosclerosis in rheumatoid arthritis (RA) remains unknown. We examined the association of the percentage of the most electronegative subfraction of HDL-c (H5%) and RA-related atherosclerosis. Using anion-exchange purification/fast-protein liquid chromatography, we demonstrated significantly higher H5% in patients (median, 7.2%) than HC (2.8%,

Indexed as

AdultArthritis, RheumatoidAtherosclerosisCell Line, TumorCholesterol, HDLChromatography, LiquidFemaleFoam CellsHumansInterleukin-1betaInterleukin-8Lipoprotein(a)MacrophagesMaleMass SpectrometryMiddle AgedCholesterol, HDLCXCL8 protein, humanIL1B protein, humanInterleukin-1betaInterleukin-8Lipoprotein(a)RNA, Messengeratherosclerosiselectronegative subfractions of HDLH5high-density lipoprotein (HDL)lipoprotein a (Lp(a))liquid chromatography/mass spectrometry (LC/MS)rheumatoid arthritis (RA)

Identifiers

PMID34768851
PMCPMC8584111
OpenAlexW3208124986

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.