ArticleInternational journal of molecular sciences2021
PVDF and P(VDF-TrFE) Electrospun Scaffolds for Nerve Graft Engineering: A Comparative Study on Piezoelectric and Structural Properties, and In Vitro Biocompatibility.
Article in International journal of molecular sciences, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers.
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Who cites it
32 citing papers in PubMed, 74 citations in OpenAlex.
- Giant Direct Magnetoelectric Effect in Nanocomposite CoFeAdvanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- A Methodological Approach to Assessing Biocompatibility: 3D Printing and Subcutaneous Implantation in Rats.ACS omega · 2026Article
- A Sustainable Alternative to PVDF for Neural Tissue Engineering via Piezoelectric PHBV and Cellulose Acetate Fibers.ACS biomaterials science & engineering · 2026Article
- Modular noncovalent functionalization of electrospun piezoelectric scaffolds with bioactive nanocarriers.Biomaterials science · 2026Article
- Exploring the piezoelectric phenomenon: From polymers to human tissues and advanced applications in tissue engineering.Bioactive materials · 2026Review
- Biomaterial-assisted neuralization strategies for tissue engineering applications.Materials today. Bio · 2026Review
- Article
- Recent Advancements in Non-surgical Approaches for the Management of Delayed Union and Nonunion in Long Bone Fractures of the Extremities: A Review.Advances in therapy · 2026Review
- FibreCastML: an open web platform for predicting electrospun nanofibre diameter distributions for biomedical applications.Frontiers in bioengineering and biotechnology · 2026Article
- Wireless Acousto-Piezoelectric Conduit with Aligned Nanofibers for Neural Regeneration.Advanced materials (Deerfield Beach, Fla.) · 2025Article
- Piezoelectric electrospun scaffold incorporating ibuprofen loaded ultrasound-responsive mesoporous silica nanoparticles for tissue regeneration.RSC advances · 2025Article
- In Vitro Behavior of Boron-Doped Baghdadite/Poly(vinylidene fluoride) Membrane Scaffolds Produced via Non-Solvent Induced Phase Separation.Macromolecular bioscience · 2025Article
- From Mechanoelectric Conversion to Tissue Regeneration: Translational Progress in Piezoelectric Materials.Advanced materials (Deerfield Beach, Fla.) · 2025Review
- Advancing Nanogenerators: The Role of 3D-Printed Nanocomposites in Energy Harvesting.Polymers · 2025Review
- Advanced development of conductive biomaterials for enhanced peripheral nerve regeneration: a review.RSC advances · 2025Review
- Characterization of Thin Polymer Layer Prepared from Liposomes and Polyelectrolytes for TGF-βMacromolecular bioscience · 2025Article
- Bioelectric cues from piezoelectric materials in stem-cell adhesion and migration.Frontiers in cell and developmental biology · 2025Review
- Review on electrical stimulation combined with electroactive biomaterials to promote peripheral nerve regeneration.Burns & trauma · 2025Review
- Biomimetic electrospun PVDF/self-assembling peptide piezoelectric scaffolds for neural stem cell transplantation in neural tissue engineering.RSC advances · 2024Article
- Cell metabolism pathways involved in the pathophysiological changes of diabetic peripheral neuropathy.Neural regeneration research · 2024Review
Corrections and comments
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Authors and funding
10 authors at 3 institutions in 1 country.
Funding
Abstract
Polyvinylidene fluoride (PVDF) and its copolymer with trifluoroethylene (P(VDF-TrFE)) are considered as promising biomaterials for supporting nerve regeneration because of their proven biocompatibility and piezoelectric properties that could stimulate cell ingrowth due to their electrical activity upon mechanical deformation. For the first time, this study reports on the comparative analysis of PVDF and P(VDF-TrFE) electrospun scaffolds in terms of structural and piezoelectric properties as well as their in vitro performance. A dynamic impact test machine was developed, validated, and utilised, to evaluate the generation of an electrical voltage upon the application of an impact load (varying load magnitude and frequency) onto the electrospun PVDF (15-20 wt%) and P(VDF-TrFE) (10-20 wt%) scaffolds. The cytotoxicity and in vitro performance of the scaffolds was evaluated with neonatal rat (nrSCs) and adult human Schwann cells (ahSCs). The neurite outgrowth behaviour from sensory rat dorsal root ganglion neurons cultured on the scaffolds was analysed qualitatively. The results showed (i) a significant increase of the β-phase content in the PVDF after electrospinning as well as a zeta potential similar to P(VDF-TrFE), (ii) a non-constant behaviour of the longitudinal piezoelectric strain constant
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.