Evidence map›Paper›PMID 34768789›Full record

ReviewInternational journal of molecular sciences2021

Progress of Phototherapy Applications in the Treatment of Bone Cancer.

Jiachen Sun, Fei Xing, Joy Braun, Frank Traub, Pol Maria Rommens, Zhou Xiang, Ulrike Ritz

Open access · goldAbstract readReview
In one paragraph

Review in International journal of molecular sciences, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.

0numbers the graph read from it
0cells of the map it votes in
27citing papers in PubMed
4.9field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

27 citing papers in PubMed, 78 citations in OpenAlex.

  1. Review
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  7. Review
  8. Mini Review On: The Roles of DNA Nanomaterials in Phototherapy.International journal of nanomedicine · 2025
    Review
  9. Review
  10. Quantum dots for bone tissue engineering.Materials today. Bio · 2024
    Review
  11. Review
  12. Review
  13. Review
  14. Article
  15. Review
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  17. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 2 countries.

Jiachen SunBiomatics Group, Department of Orthopaedics and Traumatology, University Medical Center of the Johannes Gutenberg University, Langenbeckstr. 1, 55131 Mainz, Germany.ORCID 0000-0002-5478-6198
Fei XingDepartment of Orthopaedics, West China Hospital, Sichuan University, No. 37 Guoxue Lane, Chengdu 610041, China.
Joy BraunBiomatics Group, Department of Orthopaedics and Traumatology, University Medical Center of the Johannes Gutenberg University, Langenbeckstr. 1, 55131 Mainz, Germany.ORCID 0000-0002-7500-6875
Frank TraubBiomatics Group, Department of Orthopaedics and Traumatology, University Medical Center of the Johannes Gutenberg University, Langenbeckstr. 1, 55131 Mainz, Germany.ORCID 0000-0002-6400-3257
Pol Maria RommensBiomatics Group, Department of Orthopaedics and Traumatology, University Medical Center of the Johannes Gutenberg University, Langenbeckstr. 1, 55131 Mainz, Germany.ORCID 0000-0002-5175-3876
Zhou XiangDepartment of Orthopaedics, West China Hospital, Sichuan University, No. 37 Guoxue Lane, Chengdu 610041, China.
Ulrike RitzBiomatics Group, Department of Orthopaedics and Traumatology, University Medical Center of the Johannes Gutenberg University, Langenbeckstr. 1, 55131 Mainz, Germany.ORCID 0000-0001-8936-3227
Johannes Gutenberg University Mainz · DESichuan University · CN

Funding

National Natural Science Foundation of China 31870961Project of Sichuan Provincial Science and Technology Department 2020YFS0140
6 · The paper itself

Abstract

Bone cancer including primary bone cancer and metastatic bone cancer, remains a challenge claiming millions of lives and affecting the life quality of survivors. Conventional treatments of bone cancer include wide surgical resection, radiotherapy, and chemotherapy. However, some bone cancer cells may remain or recur in the local area after resection, some are highly resistant to chemotherapy, and some are insensitive to radiotherapy. Phototherapy (PT) including photodynamic therapy (PDT) and photothermal therapy (PTT), is a clinically approved, minimally invasive, and highly selective treatment, and has been widely reported for cancer therapy. Under the irradiation of light of a specific wavelength, the photosensitizer (PS) in PDT can cause the increase of intracellular ROS and the photothermal agent (PTA) in PTT can induce photothermal conversion, leading to the tumoricidal effects. In this review, the progress of PT applications in the treatment of bone cancer has been outlined and summarized, and some envisioned challenges and future perspectives have been mentioned. This review provides the current state of the art regarding PDT and PTT in bone cancer and inspiration for future studies on PT.

Indexed as

Bone NeoplasmsGoldHumansNanoparticlesNeoplasm Recurrence, LocalOsteosarcomaPhotochemotherapyPhotosensitizing AgentsPhototherapyPhotothermal TherapyReactive Oxygen SpeciesGoldPhotosensitizing AgentsReactive Oxygen Speciesbone cancernanoparticlesphotodynamic therapyphototherapyphotothermal therapytumor therapy

Identifiers

PMID34768789
PMCPMC8584114
OpenAlexW3207386825

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.