Evidence map›Paper›PMID 34768759›Full record

ArticleInternational journal of molecular sciences2021

Mechanical Properties of Human Concentrated Growth Factor (CGF) Membrane and the CGF Graft with Bone Morphogenetic Protein-2 (BMP-2) onto Periosteum of the Skull of Nude Mice.

Md Arafat Kabir, Akihiro Hirakawa, Bowen Zhu, Kenji Yokozeki, Mamata Shakya, Bingzhen Huang, Toshiyuki Akazawa, Masahiro Todoh, Masaru Murata

Open access · goldAbstract read
In one paragraph

Article in International journal of molecular sciences, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed, 1 pooled it
1.5field-weighted citation impact, top 18% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 1 synthesis or guideline pooled it, 14 citations in OpenAlex.

  1. Pooled it
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  3. Article
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  5. Article
  6. Advances in Research on Concentrated Growth Factor Applications for Androgenetic Alopecia Treatment: A Review.Medical science monitor : international medical journal of experimental and clinical research · 2025
    Review
  7. Article
  8. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 1 country.

Md Arafat KabirDivision of Oral Regenerative Medicine, School of Dentistry, Health Sciences University of Hokkaido, Kanazawa 061-0293, Japan.ORCID 0000-0001-6986-1325
Akihiro HirakawaBiomechanical Design Faculty of Engineering, Hokkaido University, Kita 13, Nishi 8, Kita-ku, Sapporo 060-0819, Japan.
Bowen ZhuDivision of Oral Regenerative Medicine, School of Dentistry, Health Sciences University of Hokkaido, Kanazawa 061-0293, Japan.
Kenji YokozekiDivision of Oral Regenerative Medicine, School of Dentistry, Health Sciences University of Hokkaido, Kanazawa 061-0293, Japan.ORCID 0000-0003-4024-4299
Mamata ShakyaDivision of Oral Regenerative Medicine, School of Dentistry, Health Sciences University of Hokkaido, Kanazawa 061-0293, Japan.ORCID 0000-0001-5990-2285
Bingzhen HuangCorefront Corporation, 2-11 Ichitanihonmura-cho, Shinjuku-ku, Tokyo 162-0845, Japan.
Toshiyuki AkazawaIndustrial Technology and Environment Research Development, Hokkaido Research Organization, Kita 19-jo Nishi 11-chome, Kita-ku, Sapporo 060-0819, Japan.ORCID 0000-0002-2740-0413
Masahiro TodohBiomechanical Design Faculty of Engineering, Hokkaido University, Kita 13, Nishi 8, Kita-ku, Sapporo 060-0819, Japan.ORCID 0000-0001-7735-7401
Masaru MurataDivision of Oral Regenerative Medicine, School of Dentistry, Health Sciences University of Hokkaido, Kanazawa 061-0293, Japan.
Health Sciences University of Hokkaido · JPHokkaido University · JPHokkaido Research Organization · JP

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Concentrated growth factor (CGF) is 100% blood-derived, cross-linked fibrin glue with platelets and growth factors. Human CGF clot is transformed into membrane by a compression device, which has been widely used clinically. However, the mechanical properties of the CGF membranes have not been well characterized. The aims of this study were to measure the tensile strength of human CGF membrane and observe its behavior as a scaffold of BMP-2 in ectopic site over the skull. The tensile test of the full length was performed at the speed of 2mm/min. The CGF membrane (5 × 5 × 2 mm

Indexed as

AdultAnimalsBone Morphogenetic Protein 2Bone TransplantationElastic ModulusFibrin Tissue AdhesiveHealthy VolunteersHumansIntercellular Signaling Peptides and ProteinsMaleMembranesMiceMice, NudePeriosteumSkullTensile StrengthBMP2 protein, humanBone Morphogenetic Protein 2Fibrin Tissue AdhesiveIntercellular Signaling Peptides and ProteinsBMP-2bone inductionconcentrated growth factor (CGF)humanmechanical property

Identifiers

PMID34768759
PMCPMC8582862
OpenAlexW3205460766

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.