Evidence map›Paper›PMID 34768754›Full record

ArticleInternational journal of molecular sciences2021

Novel and Annotated Long Noncoding RNAs Associated with Ischemia in the Human Heart.

Zoe Ward, Sebastian Schmeier, Louis Saddic, Martin I Sigurdsson, Vicky A Cameron, John Pearson, Allison Miller, Arthur Morley-Bunker, Josh Gorham, Jonathan G Seidman and 6 more

Abstract read
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Article in International journal of molecular sciences, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Review
  2. Article
  3. Article
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  5. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors.

Zoe WardChristchurch Heart Institute, University of Otago, Christchurch 8011, New Zealand.
Sebastian SchmeierSchool of Natural and Computational Sciences, Massey University, Auckland 0745, New Zealand.
Louis SaddicDepartment of Anesthesiology and Perioperative Medicine, David Geffen School of Medicine, University of California, Los Angeles, CA 90095, USA.
Martin I SigurdssonDepartment of Anesthesiology and Critical Care Medicine, Landspitali-The National University Hospital of Iceland, Faculty of Medicine, University of Iceland, 101 Reykjavik, Iceland.
Vicky A CameronChristchurch Heart Institute, University of Otago, Christchurch 8011, New Zealand.ORCID 0000-0003-3147-683X
John PearsonBiostatistics and Computational Biology Unit, University of Otago, Christchurch 8011, New Zealand.ORCID 0000-0001-5607-4517
Allison MillerDepartment of Pathology and Biomedical Science, University of Otago, Christchurch 8011, New Zealand.
Arthur Morley-BunkerDepartment of Pathology and Biomedical Science, University of Otago, Christchurch 8011, New Zealand.
Josh GorhamDepartment of Genetics, Harvard Medical School, Boston, MA 02115, USA.
Jonathan G SeidmanDepartment of Genetics, Harvard Medical School, Boston, MA 02115, USA.ORCID 0000-0002-9082-3566
Christine S MoravecHeart and Vascular Institute, Cleveland Clinic, Cleveland, OH 44122, USA.
Wendy E SweetHeart and Vascular Institute, Cleveland Clinic, Cleveland, OH 44122, USA.
Sary F ArankiDepartment of Surgery, Division of Cardiac Surgery, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, USA.
Simon BodyDepartment of Anesthesiology, Boston University School of Medicine, Boston, MA 02115, USA.
Jochen D MuehlschlegelDepartment of Surgery, Division of Cardiac Surgery, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, USA.ORCID 0000-0002-6209-7253
Anna P PilbrowChristchurch Heart Institute, University of Otago, Christchurch 8011, New Zealand.

Funding

Molecular Signaling in Hypertrophic CardiomyopathyR01HL084553 · NHLBI · HARVARD MEDICAL SCHOOL · PI SEIDMAN, JONATHAN G · 2007 to 2022
$5.9M
Heart Foundation of New Zealand 1794NHLBI NIH HHS R01 HL084553
6 · The paper itself

Abstract

backgroundLong noncoding RNAs (lncRNAs) have been implicated in the pathogenesis of cardiovascular diseases. We aimed to identify novel lncRNAs associated with the early response to ischemia in the heart. METHODS AND

resultsRNA sequencing data gathered from 81 paired left ventricle samples from patients undergoing cardiopulmonary bypass was collected before and after a period of ischemia. Novel lncRNAs were validated with Oxford Nanopore Technologies long-read sequencing. Gene modules associated with an early ischemic response were identified and the subcellular location of selected lncRNAs was determined with RNAscope. A total of 2446 mRNAs, 270 annotated lncRNAs and one novel lncRNA differed in response to ischemia (adjusted

conclusionWe have identified 10 novel lncRNAs, one of which was associated with myocardial ischemia and may have potential as a novel therapeutic target or early marker for myocardial dysfunction.

Indexed as

Databases, GeneticGene Expression RegulationGene Regulatory NetworksHeart VentriclesHigh-Throughput Nucleotide SequencingHumansMyocardial IschemiaMyocardiumRNA, Long NoncodingRNA, MessengerSequence Analysis, RNARNA, Long NoncodingRNA, Messengerlong noncoding RNAmyocardial ischemiaRNA sequencing

Identifiers

PMID34768754
PMCPMC8583240

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.