Evidence map›Paper›PMID 34768751›Full record

ReviewInternational journal of molecular sciences2021

Editing

Ali Dehshahri, Alessio Biagioni, Hadi Bayat, E Hui Clarissa Lee, Mohammad Hashemabadi, Hojjat Samareh Fekri, Ali Zarrabi, Reza Mohammadinejad, Alan Prem Kumar

Open access · goldAbstract readReview
In one paragraph

Review in International journal of molecular sciences, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
0.6field-weighted citation impact, top 32% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 11 citations in OpenAlex.

  1. Review
  2. Review
  3. Article
  4. Novel approaches for HTLV-1 therapy: innovative applications of CRISPR-Cas9.Revista do Instituto de Medicina Tropical de Sao Paulo · 2024
    Review
  5. Article
  6. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 7 institutions in 4 countries.

Ali DehshahriCenter for Nanotechnology in Drug Delivery, Shiraz University of Medical Sciences, Shiraz 7146864685, Iran.ORCID 0000-0003-4458-1292
Alessio BiagioniDepartment of Experimental and Clinical Biomedical Sciences "Mario Serio", University of Florence, 50134 Florence, Italy.ORCID 0000-0002-6193-7417
Hadi BayatDepartment of Tissue Engineering and Applied Cell Sciences, School of Advanced Technologies in Medicine, Shahid Beheshti University of Medical Sciences, Tehran 1985717443, Iran.ORCID 0000-0003-4069-3529
E Hui Clarissa LeeCancer Science Institute of Singapore, National University of Singapore, Singapore 637551, Singapore.
Mohammad HashemabadiDepartment of Biology, Faculty of Sciences, Shahid Bahonar University, Kerman 7616914111, Iran.
Hojjat Samareh FekriStudent Research Committee, Kerman University of Medical Sciences, Kerman 7619813159, Iran.
Ali ZarrabiDepartment of Biomedical Engineering, Faculty of Engineering and Natural Sciences, Istinye University, Sariyer, Istanbul 34396, Turkey.ORCID 0000-0003-0391-1769
Reza MohammadinejadNeuroscience Research Center, Institute of Neuropharmacology, Kerman University of Medical Sciences, Kerman 7619813159, Iran.
Alan Prem KumarCancer Science Institute of Singapore, National University of Singapore, Singapore 637551, Singapore.ORCID 0000-0002-3754-5712
Kerman University of Medical Sciences · IRNational University of Singapore · SGIstinye University · TRShahid Bahonar University of Kerman · IRShiraz University of Medical Sciences · IRTarbiat Modares University · IRUniversity of Florence · IT

Funding

Ministry of Education MOE-T2EP30120-0016
6 · The paper itself

Abstract

Clustered Regularly Interspaced Short Palindromic Repeats (CRISPR) and its associated proteins (Cas) is an adaptive immune system in archaea and most bacteria. By repurposing these systems for use in eukaryote cells, a substantial revolution has arisen in the genome engineering field. In recent years, CRISPR-Cas technology was rapidly developed and different types of DNA or RNA sequence editors, gene activator or repressor, and epigenome modulators established. The versatility and feasibility of CRISPR-Cas technology has introduced this system as the most suitable tool for discovering and studying the mechanism of specific genes and also for generating appropriate cell and animal models.

Indexed as

AnimalsClustered Regularly Interspaced Short Palindromic RepeatsCRISPR-Cas SystemsGene EditingGenetic EngineeringGenomeHumansNeoplasmsSOX Transcription FactorsStem CellsSOX Transcription FactorscancerCRISPRgene editingSOX transcription factorsstem cells

Identifiers

PMID34768751
PMCPMC8583549
OpenAlexW3209129359

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.