Evidence map›Paper›PMID 34768738›Full record

ArticleInternational journal of molecular sciences2021

Prion Infectivity and PrP

Ivett Ackermann, Reiner Ulrich, Kerstin Tauscher, Olanrewaju I Fatola, Markus Keller, James C Shawulu, Mark Arnold, Stefanie Czub, Martin H Groschup, Anne Balkema-Buschmann

Open access · goldAbstract read
In one paragraph

Article in International journal of molecular sciences, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.2field-weighted citation impact, top 50% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 4 citations in OpenAlex.

  1. Article
  2. Review
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 4 institutions in 4 countries.

Ivett AckermannInstitute of Novel and Emerging Infectious Diseases, Friedrich-Loeffler-Institute, 17493 Greifswald-Insel Riems, Germany.
Reiner UlrichInstitute of Veterinary Pathology, Faculty of Veterinary Medicine, Leipzig University, 04103 Leipzig, Germany.ORCID 0000-0002-9403-1224
Kerstin TauscherDepartment of Experimental Animal Facilities and Biorisk Management, Friedrich-Loeffler-Institute, 17493 Greifswald-Insel Riems, Germany.
Olanrewaju I FatolaInstitute of Novel and Emerging Infectious Diseases, Friedrich-Loeffler-Institute, 17493 Greifswald-Insel Riems, Germany.ORCID 0000-0001-8050-9699
Markus KellerInstitute of Novel and Emerging Infectious Diseases, Friedrich-Loeffler-Institute, 17493 Greifswald-Insel Riems, Germany.ORCID 0000-0003-3229-8377
James C ShawuluInstitute of Novel and Emerging Infectious Diseases, Friedrich-Loeffler-Institute, 17493 Greifswald-Insel Riems, Germany.
Mark ArnoldAnimal and Plant Health Agency Sutton Bonington, Sutton Bonington, Leicestershire LE12 5RB, UK.
Stefanie CzubCanadian Food Inspection Agency, Lethbridge Laboratory, Lethbridge, AB T1J 3Z4, Canada.
Martin H GroschupInstitute of Novel and Emerging Infectious Diseases, Friedrich-Loeffler-Institute, 17493 Greifswald-Insel Riems, Germany.ORCID 0000-0003-0215-185X
Anne Balkema-BuschmannInstitute of Novel and Emerging Infectious Diseases, Friedrich-Loeffler-Institute, 17493 Greifswald-Insel Riems, Germany.
Friedrich-Loeffler-Institut · DEAnimal and Plant Health Agency · GBCanadian Food Inspection Agency · CALeipzig University · DE

Funding

WALA Heilmittel GmbH n.a.
6 · The paper itself

Abstract

After oral exposure of cattle with classical bovine spongiform encephalopathy (C-BSE), the infectious agent ascends from the gut to the central nervous system (CNS) primarily via the autonomic nervous system. However, the timeline of this progression has thus far remained widely undetermined. Previous studies were focused on later time points after oral exposure of animals that were already 4 to 6 months old when challenged. In contrast, in this present study, we have orally inoculated 4 to 6 weeks old unweaned calves with high doses of BSE to identify any possible BSE infectivity and/or PrP

Indexed as

Age FactorsAnimalsCattleCentral Nervous SystemDisease ProgressionEncephalopathy, Bovine SpongiformFemaleMaleMiceMice, TransgenicPeripheral NervesPrion ProteinsPrionsPrPSc ProteinsSpinal CordPrion ProteinsPrionsPrPSc ProteinsBSEcattleinfectivityperipheral and central nervous systemprion proteinprotein misfolding cyclic amplification (PMCA)PrPBSE

Identifiers

PMID34768738
PMCPMC8583047
OpenAlexW3207837841

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.