ReviewJournal of clinical medicine2021
Systematic Review of Pediatric Functional Gastrointestinal Disorders (Rome IV Criteria).
Review in Journal of clinical medicine, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
34 citing papers in PubMed, 1 synthesis or guideline pooled it, 74 citations in OpenAlex.
- Pooled it
- The effect of anti-nausea wristbands and STW-5 in children suffering from dyspepsia - a randomized double-blind placebo-controlled pilot-study.Klinische Padiatrie · 2026Trial
- Effect of Lactobacillus reuteri NCIMB 30351 drops on symptoms of infantile functional gastrointestinal disorders and gut microbiota in early infants: Results from a randomized, placebo-controlled clinical trial.European journal of pediatrics · 2024Trial
- Article
- Sleep, Stress, Circadian Rhythm, and Diet in Pediatric Disorders of Gut-Brain Interaction: A Narrative Review.Nutrients · 2026Review
- Emotional and Behavioural Problems in Children With Functional Gastrointestinal Disorders.Acta paediatrica (Oslo, Norway : 1992) · 2026Article
- Beyond the Organic: A Biopsychosocial Analysis of Pediatric Functional Gastrointestinal Disorders-A Retrospective Chart Review.Children (Basel, Switzerland) · 2026Article
- Antibiotics in the first week of life are not associated with functional gastrointestinal disorders at 9-12 years of age.Journal of pediatric gastroenterology and nutrition · 2026Observational
- Internet-delivered cognitive behavioral therapy for pediatric functional abdominal pain disorders: Parental factors in treatment response.Internet interventions · 2026Article
- SIRT1-mediated deacetylation of DRP1 suppresses excessive mitophagy and ameliorates pediatric functional dyspepsia.BMC immunology · 2026Article
- Adult Rome IV Disorders of Gut-Brain Interaction in a Pediatric Population.Children (Basel, Switzerland) · 2026Article
- Clinical indications and outcomes of pediatric gastrointestinal endoscopy in a resource-limited healthcare system: Findings from the first multicenter study.SAGE open medicine · 2026Article
- Delayed orocecal transit in pediatric gut-brain interaction disorders: A comparative study using the lactulose breath test.World journal of gastrointestinal pathophysiology · 2025Article
- Validating a novel scoring system for the assessment and treatment of functional gastrointestinal disorders in children.World journal of clinical pediatrics · 2025Article
- Validity and reliability of the Thai "Rome IV diagnostic questionnaires" for functional gastrointestinal disorders in neonates and toddlers.World journal of clinical cases · 2025Article
- Prenatal exposure to selective serotonin reuptake inhibitors and risk of disorders of gut-brain interaction in children.Molecular psychiatry · 2025Article
- Prevalence and possible causes of crying and mild gastrointestinal and skin symptoms in infants reported by healthcare professionals - worldwide data.European journal of pediatrics · 2025Article
- Anxiety, Depressive Symptomatology, and Perfectionism Traits and Their Relationship with Disorders of Gut-Brain Interaction in Children.Pediatric gastroenterology, hepatology & nutrition · 2025Article
- Parental distress and symptom severity in referred youths with functional abdominal pain disorders: a cross-sectional study prior to internet-based cognitive behavioral therapy.Therapeutic advances in gastroenterology · 2025Article
- Effects of dietary fiber on Chinese children with functional constipation and targeted modification of gut microbiota and related metabolites.Frontiers in nutrition · 2025Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Functional gastrointestinal disorders (FGID) are common among children and may cause a significant symptom burden. The Rome criteria are symptom-based guidelines for the assessment of FGID among children and adults. The aim of this systematic review was to estimate the prevalence of FGID utilizing the revised Rome IV criteria. Nine health databases were searched. The inclusion criteria were: prospective FGID prevalence data using the Rome IV criteria for children up to 18 years, and the exclusion criteria were: cohorts with known gastrointestinal or organic conditions. The data were presented as a percentage of children experiencing at least one FGID, as well as in individual categories. The searches identified 376 papers, with 20 included in the final analysis, providing a pooled cohort of 18,935 children. The median prevalence of FGID for children aged up to four years was 22.2% (range 5.8-40%), and aged four-eighteen years was 21.8% (range 19-40%). The most common FGID for children aged 0-12 months was infant regurgitation, the most common FGID for those aged 13-48 months were functional constipation and cyclic vomiting, and, for those aged over four years, functional constipation, functional dyspepsia, and irritable bowel syndrome. This reported overall incidence of FGID may be used as a benchmark of normative data among the general population and comparative data for those with comorbid disease.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.