Evidence map›Paper›PMID 34768578›Full record

ArticleJournal of clinical medicine2021

A High Risk of Missing Congenital Cytomegalovirus-Associated Hearing Loss through Newborn Hearing Screening in Japan.

Shujiro Bando Minami, Yoshiharu Yamanobe, Atsuko Nakano, Hirokazu Sakamoto, Sawako Masuda, Tetsuya Takiguchi, Sayaka Katsunuma, Tomoko Sugiuchi, Noriko Morita, Kimitaka Kaga and 1 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of clinical medicine, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
2.1field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 20 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 9 institutions in 1 country.

Shujiro Bando MinamiDepartment of Otolaryngology, National Hospital Organization Tokyo Medical Center, 2-5-1 Higashigaoka, Meguro, Tokyo 152-8902, Japan.
Yoshiharu YamanobeDepartment of Otolaryngology, Head and Neck Surgery, School of Medicine, Keio University, 35 Shinanomachi, Shinjuku-ku, Tokyo 160-8582, Japan.
Atsuko NakanoDivision of Otolaryngology, Chiba Children's Hospital, 579-1 Hetacho, Midori-ku, Chiba-shi 266-0007, Chiba, Japan.
Hirokazu SakamotoDepartment of Otolaryngology, Graduate School of Medicine Osaka City University, 1-4-3, Asahimachi, Abeno-ku, Osaka-shi 545-8585, Osaka, Japan.
Sawako MasudaDepartment of Otorhinolaryngology, National Hospital Organization Mie National Hospital, 357 Osato-Kubota, Tsu 514-0125, Mie, Japan.
Tetsuya TakiguchiDepartment of Otolaryngology, National Hospital Organization Kanazawa Medical Center, 1-1 Shimoishibiki-machi, Kanazawa-shi 920-8650, Ishikawa, Japan.
Sayaka KatsunumaDepartment of Otolaryngology, Hyogo Prefectural Kobe Children's Hospital, 1-6-7 Minatojima Minami-cho, Chuo-ku, Kobe-shi 650-0047, Hyogo, Japan.
Tomoko SugiuchiDepartment of Otorhinolaryngology, Kanto Rosai Hospital, 1-1 Kizukisumiyoshi-cho, Nakahara-ku, Kawasaki-shi 211-8510, Kanagawa, Japan.
Noriko MoritaDepartment of Otorhinolaryngology, Teikyo University Hospital, 2-11-1 Kaga, Itabashi-ku, Tokyo 173-8606, Japan.
Kimitaka KagaDivision of Hearing and Balance Research, National Institute of Sensory Organs, National Hospital Organization Tokyo Medical Center, 2-5-1 Higashigaoka, Meguro, Tokyo 152-8902, Japan.
Tatsuo MatsunagaDivision of Hearing and Balance Research, National Institute of Sensory Organs, National Hospital Organization Tokyo Medical Center, 2-5-1 Higashigaoka, Meguro, Tokyo 152-8902, Japan.ORCID 0000-0001-9647-1496
Tokyo Medical Center · JPChiba Hospital · JPJapan Organization of Occupational Health and Safety · JPKanazawa Medical Center · JPKeio University · JPKobe Children's Hospital · JPKubota (Japan) · JPOsaka City University · JPTeikyo University Hospital · JP

Funding

JSPS KAKENHI 19K09881National Hospital Organization H30-NHO (kankakuki)-01National Hospital Organization R2-NHO-Sensory Organs-01
6 · The paper itself

Abstract

It remains unclear to what extent newborn hearing screening (NHS) detects congenital cytomegalovirus (cCMV)-associated sensorineural hearing loss (SNHL) in Japan. This study aimed to clarify the NHS results and audiological characteristics of patients with cCMV-associated SNHL. A total of 541 individuals with unilateral or bilateral hearing loss of unknown etiology were examined for cCMV infection. cCMV infection was defined by the presence of CMV DNA in the dried umbilical cord detected using real-time quantitative PCR. NHS results and audiological data were retrospectively obtained from medical records. Forty-four cases (8.1%) were positive for cCMV infection. Of them, 33 cases underwent NHS and 13 cases (39.4%) passed NHS bilaterally. The pure-tone audiograms of 21 patients were obtained. There were seven cases of unilateral SNHL, five cases of asymmetric bilateral SNHL, and nine cases of symmetric bilateral SNHL. cCMV-related hearing loss is highly heterogeneous, and there is a high risk of missing this condition through NHS.

Indexed as

cytomegalovirusnewborn hearing screeningumbilical cord

Identifiers

PMID34768578
PMCPMC8584481
OpenAlexW3210770103

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.