Evidence map›Paper›PMID 34768558›Full record

ReviewJournal of clinical medicine2021

Autologous Fat Injection Laryngoplasty for Unilateral Vocal Fold Paralysis.

Wen-Dien Chang, Sheng-Hwa Chen, Ming-Hsui Tsai, Yung-An Tsou

Open access · goldAbstract readReview
In one paragraph

Review in Journal of clinical medicine, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
1.1field-weighted citation impact, top 23% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 19 citations in OpenAlex.

  1. Nanofat for Injection Laryngoplasty: Office and Operative Results.Laryngoscope investigative otolaryngology · 2026
    Article
  2. Voice outcomes after office-based hyaluronic acid injection for vocal fold immobility: a prospective single-center study.European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery · 2026
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 4 institutions in 1 country.

Wen-Dien ChangDepartment of Sport Performance, National Taiwan University of Sport, Taichung 404401, Taiwan.
Sheng-Hwa ChenDepartment of Audiology and Speech-Language Pathology, Asia University, Taichung 41354, Taiwan.
Ming-Hsui TsaiDepartment of Audiology and Speech-Language Pathology, Asia University, Taichung 41354, Taiwan.
Yung-An TsouDepartment of Audiology and Speech-Language Pathology, Asia University, Taichung 41354, Taiwan.
Asia University · TWChina Medical University · TWChina Medical University Hospital · TWNational Taiwan University of Sport · TW

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundUnilateral vocal palsy (UVFP) affects the voice and swallowing function and could be treated by various materials to achieve improved mucosal wave and better closure during phonation. Injection laryngoplasty is considered an exemplary method for these patients and could be injected as early as possible. We conducted a systematic review and meta-analysis for the subjective and objective outcomes of autologous fat injection laryngoplasty (AFIL) and assessed the effects for patients with UVFP.

methodsWe searched studies from PubMed and EBSCO databases with PRISMA appraisal to search for articles about the effects of AFIL on UVFP. The published articles were reviewed according to our inclusion and exclusion criteria. The short- and long-term outcomes of perceptual, acoustic analysis, and quality of life were also analyzed by meta-analysis.

resultsEleven articles were reviewed, and seven studies were selected for meta-analysis. AFIL improves the perceptual outcome and some voice parameters in short-term and long-term results, i.e., jitter, shimmer, and maximal phonation time (MPT). It also significantly improved the voice handicap index (VHI) in the long term, suggesting an increase in quality of life.

conclusionsAFIL is considered a reliable treatment method for UVFP and could even last for over 12 months.

Indexed as

acoustic analysisautologous fat injection laryngoplastyunilateral vocal fold paralysis

Identifiers

PMID34768558
PMCPMC8584613
OpenAlexW3210909079

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.