Evidence map›Paper›PMID 34768555›Full record

ArticleJournal of clinical medicine2021

Did the COVID-19 Pandemic Increase the Incidence of Acute Macular Neuroretinopathy?

Georges Azar, Sophie Bonnin, Vivien Vasseur, Céline Faure, Flore Salviat, Catherine Vignal Clermont, Cherif Titah, Selim Farès, Elise Boulanger, Sabine Derrien and 7 more

Open access · goldAbstract read
In one paragraph

Article in Journal of clinical medicine, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers.

0numbers the graph read from it
0cells of the map it votes in
34citing papers in PubMed
9.4field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

34 citing papers in PubMed, 61 citations in OpenAlex.

  1. Ultra-high-resolution imaging of acute macular neuroretinopathy: a case report.American journal of ophthalmology case reports · 2026
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  7. Atypical presentation of acute macular neuroretinopathy: a case description.Quantitative imaging in medicine and surgery · 2025
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  12. Optical coherence tomography angiography suggests choriocapillaris perfusion deficit as etiology of acute macular neuroretinopathy.Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie · 2024
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  18. Review
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  20. Acute macular neuroretinopathy following Moderna COVID-19 vaccination.Journal of ophthalmic inflammation and infection · 2023
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors at 4 institutions in 1 country.

Georges AzarClinical Investigative Platform Department, Adolphe de Rothschild Foundation, 75019 Paris, France.ORCID 0000-0002-9808-5545
Sophie BonninClinical Investigative Platform Department, Adolphe de Rothschild Foundation, 75019 Paris, France.ORCID 0000-0003-2614-9412
Vivien VasseurClinical Investigative Platform Department, Adolphe de Rothschild Foundation, 75019 Paris, France.ORCID 0000-0002-7647-3088
Céline FaureRamsay Générale de Santé, Private Hospital Saint Martin, 14000 Caen, France.ORCID 0000-0002-7435-7518
Flore SalviatClinical Investigative Platform Department, Adolphe de Rothschild Foundation, 75019 Paris, France.
Catherine Vignal ClermontClinical Investigative Platform Department, Adolphe de Rothschild Foundation, 75019 Paris, France.
Cherif TitahClinical Investigative Platform Department, Adolphe de Rothschild Foundation, 75019 Paris, France.
Selim FarèsClinical Investigative Platform Department, Adolphe de Rothschild Foundation, 75019 Paris, France.ORCID 0000-0003-0159-2047
Elise BoulangerClinical Investigative Platform Department, Adolphe de Rothschild Foundation, 75019 Paris, France.
Sabine DerrienClinical Investigative Platform Department, Adolphe de Rothschild Foundation, 75019 Paris, France.
Aude CouturierClinical Investigative Platform Department, Adolphe de Rothschild Foundation, 75019 Paris, France.
Amélie DuvilliersClinical Investigative Platform Department, Adolphe de Rothschild Foundation, 75019 Paris, France.
Anthony ManasseroClinical Investigative Platform Department, Adolphe de Rothschild Foundation, 75019 Paris, France.
Rabih HageClinical Investigative Platform Department, Adolphe de Rothschild Foundation, 75019 Paris, France.
Ramin TadayoniClinical Investigative Platform Department, Adolphe de Rothschild Foundation, 75019 Paris, France.
Francine Behar-CohenOphthalmology Department, OphtalmoPôle, Hôpital Cochin, Assistance Publique-Hôpitaux de Paris, AP-HP, Université de Paris, 75014 Paris, France.ORCID 0000-0001-8571-9513
Martine Mauget-FaÿsseClinical Investigative Platform Department, Adolphe de Rothschild Foundation, 75019 Paris, France.
Fondation de Rothschild · FRAssistance Publique – Hôpitaux de Paris · FRGénérale de Santé · FRInserm · FR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundAcute macular neuroretinopathy (AMN) is an increasingly diagnosed disorder associated with several diseases. The aim of this study was to report the incidence of AMN cases diagnosed during the 2020 coronavirus disease 2019 (COVID-19) pandemic year in a French hospital, and to describe their different forms.

methodsAll patients diagnosed between 2019 and 2020, in Paris Rothschild Foundation Hospital, with AMN, paracentral acute middle maculopathy (PAMM) and multiple evanescent white dot syndrome (MEWDS) were retrospectively collected using the software Ophtalmoquery

resultsEleven patients were diagnosed with AMN in 2020 vs. only one patient reported in 2019. The incidence of AMN significantly increased from 0.66/100,000 visits in 2019 to 8.97/100,000 visits in 2020 (

conclusionsThe incidence of AMN cases increased significantly in our institution in 2020, which was the year of the COVID-19 pandemic. All AMN-tested patients received a positive COVID PCR test, suggesting a possible causative link. According to the different clinical presentations, AMN may reflect different severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) pathogenic mechanisms.

Indexed as

acute macular neuroretinopathyAMNCOVID-19OCT angiographypandemicretinaSARS-CoV-2

Identifiers

PMID34768555
PMCPMC8585041
OpenAlexW3210243014

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.